Abstract
The p53 signature (p53S) has been proposed to be a marker of the earliest phase of development of endometrial serous carcinoma. We examined the presence of p53S in the background endometrium in cases of endometrial carcinoma. From a series of 351 endometrial carcinomas, 225 (64.1 %) lesions, for which slides of the adjacent noncancerous endometrium were available for review, were included. Expression of estrogen receptor (ER)-alpha, Ki-67, and p53 in the adjacent endometrium was studied by immunohistochemistry. The p53S was defined as the presence of morphologically benign endometrial epithelial cells with moderate to strong intensity of p53 immunostaining. Of the 225 noncancerous endometrium samples, 34 consisted of hyperplastic and 191 of non-hyperplastic endometrium. A p53S was found in 22 cases (mean age 64.2 years), 2 in hyperplastic, and 20 in non-hyperplastic background endometrium. All p53S-positive cases also expressed ER-alpha; their median Ki-67 labeling index (LI) was 4.0 % (range 0.0 to 21.0 %). The two cases with hyperplastic p53S-positive background endometrium were in association with a grade 1 endometrioid tumor in a premenopausal woman with Lynch syndrome. Of the 152 cases of endometrioid adenocarcinomas with ...Continue Reading
References
Dec 1, 2000·Nature·B VogelsteinA J Levine
Oct 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peter W SchlosshauerRobert A Soslow
Nov 4, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Hugo MaiaElsimar M Coutinho
Sep 15, 2005·The Journal of Pathology·R NenutilB Vojtesek
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kristin K ZornMichael J Birrer
Nov 3, 2006·Journal of Molecular Histology·Markus Seifert, Jörg Reichrath
Aug 2, 2007·The American Journal of Surgical Pathology·Camilla E CominLuca Messerini
Mar 18, 2008·Gynecologic Oncology·Ann K FolkinsChristopher P Crum
Jan 20, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elke A JarboeChristopher P Crum
Apr 7, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chih-Ping HanShun-Fa Yang
May 14, 2009·The American Journal of Pathology·Xi ZhangWenxin Zheng
Jul 23, 2009·The American Journal of Surgical Pathology·Anna YemelyanovaBrigitte M Ronnett
Dec 18, 2010·The American Journal of Surgical Pathology·Wenxin ZhengBeihua Kong
May 14, 2011·The American Journal of Surgical Pathology·Liping ZhangDi Lu
May 11, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Christopher P CrumWa Xian
Aug 28, 2012·Journal of the National Cancer Institute·Elisabetta KuhnIe-Ming Shih
Jun 15, 2013·Familial Cancer·Karen H Lu, Molly Daniels
Feb 5, 2014·International Journal of Cancer. Journal International Du Cancer·Verena SteinkeUNKNOWN German HNPCC Consortium
Mar 26, 2014·Cancer Research·George L MutterCharis Eng
Mar 29, 2014·Gynecologic Oncology·Koji MatsuoAnil K Sood
Jun 4, 2014·Menopause : the Journal of the North American Menopause Society·Chiho KoiYoshihisa Fujino
Citations
Dec 8, 2015·Experimental and Therapeutic Medicine·Jia LiuYanhong Che
Apr 28, 2019·The Journal of Biological Chemistry·Nataly Melo Dos SantosEtel Rodrigues Pereira Gimba
Apr 4, 2021·Cancers·Laura PaleariEmanuela Marcenaro