PMID: 11335903May 4, 2001Paper

Significance of perivascular lymphocytic infiltrates in endometrial carcinoma

Cancer
K YamazawaS Sekiya

Abstract

The objective of this study was to clarify the significance of perivascular lymphocytic infiltrates (PLI) in endometrial carcinoma. The pathologic records of 127 patients with endometrioid type adenocarcinoma confined to the uterus were reviewed retrospectively. The patients were divided into 4 groups based on the presence or absence of vascular invasion (VI) and PLI: VI-PLI- (n = 87), VI-PLI+ (n = 7), VI+PLI+ (n = 22), and VI+PLI- (n = 11). Pathologic features including tumor grade, myometrial invasion, cervical involvement, vascular invasion-associated changes (VIAC; VI and/or PLI), tumor size, ovarian metastasis, and pelvic lymph node metastasis were assessed statistically. Selective pelvic lymphadenectomy was performed in 108 patients, and metastasis was identified in 6 cases (5.6%). Lymph node metastasis was the only independent variable related to recurrence (Cox regression analysis, P = 0.0008). Perivascular lymphocytic infiltrates correlated closely with VI (Fisher exact test, P < 0.0001). Vascular invasion-associated changes was the best predictor of lymph node metastasis (logistic regression analysis, P = 0.039), but among the three categories of VIAC, only the VI+PLI- group was significantly associated with lymph nod...Continue Reading

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Citations

May 12, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Giacomo PuppaGiuseppe Pelosi
Sep 23, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Shawn K MurrayRobert E Scully
Sep 12, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Marcin JedrykaJan Kornafel
Dec 4, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W Glenn McCluggageLynn Hirschowitz
Jun 29, 2011·Pathology International·Domenico RibattiEnrico Crivellato
Jun 29, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·L H HonoréS E Andrew
Jan 23, 2018·Advances in Anatomic Pathology·W Glenn McCluggage
Jul 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Svetlana KondratievMurray B Resnick
May 23, 2007·Archives of Pathology & Laboratory Medicine·Steven G Silverberg

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