Significance of phosphatidylglycerol in amniotic fluid in complicated pregnancies

American Journal of Obstetrics and Gynecology
R BustosE Lowenberg


In normal pregnancy lecithin/sphingomyelin ratios correlate with gestational age. In complicated pregnancies biochemical maturation of fetal lung may be accelerated or delayed, depending upon maternal, fetal, or placental conditions. Surfactant contains other phospholipids besides lecithin, including phosphatidylglycerol (PG), the second major component of mature surfactant. Ninety phospholipid patterns in amniotic fluid were studied by two-dimensional thin-layer chromatography. In uncomplicated pregnancies PG was absent until 37 weeks' gestation, then increased there after. In complicated pregnancies (pre-eclampsia, diabetes Classes D, F, and R, premature rupture of membranes) PG was identified before 35 (as early as 29 weeks' gestation. These results verify accelerated lung maturation in certain complicated pregnancies. No newborn infant developed respiratory distress syndrome in the presence of PG.


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Related Concepts

Amniotic Fluid Index
Antibody Formation
Thin Layer Chromatography
Preterm Premature Rupture of Fetal Membranes

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Scandinavian Journal of Clinical and Laboratory Investigation
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