Significance of podoplanin expression in keratocystic odontogenic tumor

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Eri OkamotoKaoru Kusama

Abstract

The most important clinical features of the keratocystic odontogenic tumor (KCOT) are its potential for locally destructive behavior, a tendency to recur, and its origin in the odontogenic epithelium. The clinical features of KCOT are similar to those of ameloblastoma (AM). Histologically, KCOT is distinguished from jaw cyst with keratinization (orthokeratinized odontogenic cyst; OOC). However, current scientifically based clinical parameters cannot predict any potential for neoplastic behavior, or aggressive and localized invasiveness, in patients with KCOT. We have shown that podoplanin, a lymphatic endothelial marker, is highly expressed in AM. The purpose of this study was to determine the usefulness of podoplanin for reclassification of the odontogenic keratocyst (OKC) from cyst to tumor status. Paraffin-embedded tissue specimens of 57 OKCs (46 KCOTs and 11 OOCs) and 15 dentigerous cysts (DCs) were immunohistochemically examined using antibody against podoplanin. Immunohistochemical reactivity for podoplanin was detected in the cell membrane and cytoplasm of most of the basal and suprabasal layer, areas of budding basal cell proliferation, epithelial nests and peripheral cells of daughter cysts in the stromal connective ti...Continue Reading

References

Oct 30, 2004·International Journal of Cancer. Journal International Du Cancer·Ester Martín-VillarMiguel Quintanilla
Jul 12, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yukinari KatoMotoki Osawa
Mar 11, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kimberly L DumoffGeza Acs
Oct 19, 2006·Journal of Cell Science·Ester Martín-VillarMiguel Quintanilla
Dec 21, 2006·British Journal of Cancer·A Wicki, G Christofori
Jan 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hidetoshi KawaguchiLi Mao
Jun 25, 2009·Journal of Oral Science·Yuji MiyazakiKaoru Kusama

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Citations

Nov 15, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Harumi InoueKaoru Kusama
Apr 23, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Chong Huat Siar, Syed Amjad Abbas
Apr 7, 2011·Journal of Oral Science·Patricia González-AlvaKaoru Kusama
Aug 8, 2014·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·J LogeswariS Vijaya Nirmala
Aug 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Harumi InoueKaoru Kusama
Jan 13, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ernesto Santos Sousa-NetoJean Nunes Dos Santos
Feb 14, 2012·Pathology, Research and Practice·Masayuki TsunekiTakashi Saku
Oct 20, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Fumio IdeKaoru Kusama
Jul 22, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ana Ivanišević MalčićSandra Kraljević Pavelić
Dec 7, 2014·BMC Oral Health·Denise Tostes OliveiraFernando Augusto Soares
May 16, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Michael W FinkelsteinSteven D Vincent
Jul 6, 2012·Archives of Oral Biology·Adriana dos Santos CaetanoDenise Tostes Oliveira
Nov 20, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Celeste Sánchez-RomeroOslei Paes de Almeida
Mar 27, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shahroo Etemad-Moghadam, Mojgan Alaeddini
May 7, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Brendan D'souzaVijayalakshmi S Kotrashetti
Jul 26, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chong Huat SiarKok Han Ng
Jun 27, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Giulia G MalaguezMarcia G Oliveira
Feb 20, 2021·The American Journal of Dermatopathology·Clare A GogginsScott A Norton

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