Significance of Portal Vein Invasion and Extent of Invasion in Patients Undergoing Pancreatoduodenectomy for Pancreatic Adenocarcinoma

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Alexandra M RochC Max Schmidt

Abstract

Several studies have confirmed the safety of pancreatoduodenectomy with portal/mesenteric vein resection and reconstruction in select patients. The effect of vein invasion and extent of invasion on survival is less clear. The purpose of this study was to examine the association between tumor invasion of the portal/mesenteric vein and long-term survival. A retrospective review of a prospectively maintained database of patients who underwent pancreatoduodenectomy for pancreatic adenocarcinoma at a single academic medical center (2000-2014) was performed. Survival was compared using the Kaplan-Meier method and log-rank test. P < 0.05 was considered statistically significant. After non-pancreatic periampullary adenocarcinomas and patients with non-segmental (lateral wall only) resection of portal/mesenteric vein were excluded, there were 567 eligible patients. Of these, segmental vein resection was performed in 90 (16 %) with end-to-end primary anastomosis (67) or interposition graft reconstruction (23). Patients with vein resection more likely received neoadjuvant systemic therapy (59 vs. 4 %, p < 0.0001). Histopathology of patients undergoing vein resection revealed a distribution of T stage toward larger tumors and higher rates ...Continue Reading

References

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May 27, 2014·Surgery·Maximilian BockhornUNKNOWN International Study Group of Pancreatic Surgery

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Citations

Sep 18, 2018·European Journal of Gastroenterology & Hepatology·David MartinMarkus Schäfer
Mar 2, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Laura R PrakashMatthew H G Katz
May 24, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jesse V GroenUNKNOWN Dutch Pancreatic Cancer Group
Oct 9, 2021·Medicine·João Emílio Lemos Pinheiro FilhoJaques Waisberg
Nov 9, 2021·Future Oncology·Monish Karunakaran, Savio George Barreto

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