PMID: 870163May 1, 1977Paper

Significance of quantitative assessment of estrogen receptors for endocrine therapy in advanced breast cancer

Cancer
J C HeusonG Leclercq

Abstract

The predictive significance of quantitative assessment of estrogen receptors in tumor tissue was analyzed in women with advanced breast carcinoma. Receptor concentration was measured by the 3H-estradiol binding capacity of the cytosol fraction of biopsies taken before initiation of the treatment. The E. O. R. T. C. criteria for the assessment of the patients' response were used. In a total of 34 assessments, 25 biopsies contained receptors; the remaining ones were negative. Objective remission to various endocrine therapies was recorded in only eight of the receptor-positive patients. Responses occurred along the whole scale of receptor concentrations with an apparent crowding in the region of the higher values. Linear logistic regression analysis revealed that among 12 variables of known prognostic value, receptor concentration was the most significant in relation to therapeutic response. Other significant variables were bone involvement and age. Computations yielded formulas that are presented in graph form and provide an estimate of the probability of a given patient to respond to endocrine treatments. On the other hand, the results suggest that all patients are possibly hormone dependent, although to variable degrees. The l...Continue Reading

References

Jan 25, 1975·British Medical Journal·G LeclercqW H Mattheiem
Sep 1, 1975·Journal of the National Cancer Institute·S G Korenman
Nov 29, 1975·British Medical Journal·J P PersijnE Engelsman
May 1, 1973·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Sep 1, 1973·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G LeclercqH J Tagnon

❮ Previous
Next ❯

Citations

Jan 1, 1989·Journal of Cancer Research and Clinical Oncology·A VasishtaA Cuschieri
Jan 1, 1986·Breast Cancer Research and Treatment·G Di FronzoF Rilke
Jan 1, 1983·Breast Cancer Research and Treatment·S M ThorpeB B Rasmussen
May 9, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Masafumi Kurosumi
Dec 22, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·A A Keshgegian
Mar 28, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·B P GilabertV C Albadalejo
May 1, 1978·Journal of Steroid Biochemistry·W L McGuireG C Chamness
Oct 1, 1980·Journal of Steroid Biochemistry·H Braunsberg, K D Hammond
Jan 1, 1985·Journal of Steroid Biochemistry·K S PetterssonJ R Söderholm
Dec 19, 1979·Biochimica Et Biophysica Acta·D P EdwardsW L McGuire
May 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·J A ChapmanD J Sutherland
May 1, 1979·Ophthalmology·A S Grove
Dec 4, 2001·Biochimica Et Biophysica Acta·S DaubeufM M Galteau
Sep 11, 2012·Analytical Chemistry·Yongqiang DongGuonan Chen
Jul 1, 1977·Journal of Toxicology and Environmental Health·E H ChuC C Chang
Jan 1, 1978·Journal of Toxicology and Environmental Health·G R LankasR T Christian
Sep 1, 1980·Journal of Toxicology and Environmental Health·O Pelkonen, K Vähäkangas
Feb 1, 1981·Journal of Toxicology and Environmental Health·J A BondM R Juchau
Feb 3, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H AndersonM Dowsett
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Sheri, M Dowsett
Oct 23, 1997·Anatomia, histologia, embryologia·M K OcalS Daglioglu
Dec 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·M C KohnC J Portier
Oct 1, 1978·Photochemistry and Photobiology·J E BiaglowM Varnes
Aug 1, 1978·Photochemistry and Photobiology·J E Trosko, C C Chang
Jan 1, 1980·Journal of Receptor Research·C S Watson, J H Clark
Jan 1, 1978·Medical and Pediatric Oncology·Y T Lee, F S Markland
Aug 1, 1986·Pathology, Research and Practice·H E StegnerJ Bahnsen
Dec 1, 1976·Current Problems in Cancer·G Leclercq, J C Heuson
Apr 1, 1978·Metabolism: Clinical and Experimental·W L McGuireG C Chamness
Jul 1, 1983·European Journal of Cancer & Clinical Oncology·J P JanssensW De Loecker
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B G MobbsP V Murthy
Jun 1, 1981·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J P JanssensW De Loecker
Nov 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G Leclercq, J C Heuson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
H WesterbergP O Granberg
Progress in Clinical and Biological Research
E V JensenE R DeSombre
© 2021 Meta ULC. All rights reserved