Significance of sarcopenia as a prognostic factor for metastatic urothelial carcinoma patients treated with systemic chemotherapy

International Journal of Clinical Oncology
Hideyuki AbeTakao Kamai

Abstract

Recently, numerous studies have reported an association between sarcopenia and poor outcomes in various kinds of malignancies. We investigated whether sarcopenia predicts the survival of patients with metastatic urothelial carcinoma who underwent systemic chemotherapy. We reviewed 87 metastatic urothelial carcinoma patients who underwent chemotherapy (gemcitabine plus cisplatin or gemcitabine plus carboplatin for cisplatin-unfit patients) between 2007 and 2015. A computed tomography scan prior to chemotherapy was used for evaluating sarcopenia, and we measured three cross-sectional areas of skeletal muscle at the third lumbar vertebra and calculated the skeletal muscle index (SMI), the paraspinal muscle index (PSMI), and the total psoas area (TPA) of each patient. Predictive values of survival were assessed using Cox regression analysis. The median overall survival (OS) was 16 months (95% CI 13.5-18). Although SMI alone was not a significant predictor of shorter OS (P = 0.117) in univariate analysis, SMI stratified by the value of the body mass index (BMI) was a significant predictor of shorter OS in univariate analysis (P = 0.037) and was also an independent predictor of shorter OS in multivariate analysis (P = 0.026). PSMI an...Continue Reading

References

May 1, 1997·The Journal of Nutrition·I H Rosenberg
Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans von der MaaseMichael Arning
Oct 17, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Marina MourtzakisVickie E Baracos
Jan 22, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S AntounM B Sawyer
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Feb 8, 2011·The Lancet Oncology·Kenneth FearonVickie E Baracos
May 11, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew D GalskyJoaquim Bellmunt
Jun 22, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Peter D PengTimothy M Pawlik
Jun 14, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Peter PengTimothy M Pawlik
Jan 16, 2014·The Journal of Urology·Angela B SmithMatthew E Nielsen
Feb 28, 2014·The American Journal of Clinical Nutrition·Maria Cristina GonzalezSteven B Heymsfield
Jan 23, 2015·PloS One·Hiroshi FukushimaFumitaka Koga
Apr 29, 2015·The Proceedings of the Nutrition Society·S Goya Wannamethee, Janice L Atkins
May 1, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Neda AminiTimothy M Pawlik
Jul 5, 2015·Japanese Journal of Clinical Oncology·Megumi HoriUNKNOWN Japan Cancer Surveillance Research Group
Aug 21, 2015·The Journal of Urology·Hiroshi FukushimaFumitaka Koga
Jan 18, 2016·European Urology·Christine M FriedenreichKerry S Courneya
May 17, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Bette J CaanCarla M Prado

❮ Previous
Next ❯

Citations

Oct 3, 2018·International Journal of Molecular Sciences·Hiroshi FukushimaFumitaka Koga
Oct 5, 2021·International Journal of Clinical Oncology·Ryutaro ShimizuAtsushi Takenaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.