PMID: 6113606Jan 1, 1980Paper

Significance of serum gamma glutamyl transpeptidase as a marker of alcoholism

Pharmacology, Biochemistry, and Behavior
H IshiiM Tsuchiya

Abstract

To study the effect of chronic ethanol administration on the activity of gamma glutamyl transpeptidase (GGTP) in various tissues, female rats were pair-fed liquid diets with 36% of total calories either as ethanol or as isocaloric carbohydrate (controls). Six weeks of ethanol feeding resulted in a significant increase of cytochrome P450 content. Hepatic microsomal GGTP activity was almost doubled after ethanol feeding whether expressed per g of liver or per mg of microsomal protein. Furthermore, intestinal GGTP activity was significantly enhanced after ethanol, whereas there was no change in the enzyme activity in either kidney or pancreas. There was a concomitant elevation of plasma GGTP activity. Phenobarbital administration to rats resulted in an enhancement of GGTP activity in the liver whether given orally or intraperitoneally. In addition, intestinal GGTP activity after oral phenobarbital was also significantly increased, although its activity after intraperitoneal administration was not enhanced. These results suggest that enhanced hepatic and intestinal GGTP activities may contribute, at least in part, to an increased level of serum GGTP frequently seen in chronic alcoholics.

References

Apr 11, 1977·Biochemical and Biophysical Research Communications·R TeschkeG Strohmeyer
Aug 8, 1977·Biochemical and Biophysical Research Communications·J MorlandJ H Stromme
Nov 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Szewczuk
Nov 1, 1962·Clinica Chimica Acta; International Journal of Clinical Chemistry·M ORLOWSKI, A SZEWCZUK

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Citations

Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MoriH Ishii
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·D P AgarwalH W Goedde
Apr 12, 2007·Obstetrical & Gynecological Survey·Sajal GuptaJuan G Alvarez
Aug 1, 1986·Alcoholism, Clinical and Experimental Research·R R WatsonB Hartmann
Jan 1, 1986·Alcoholism, Clinical and Experimental Research·H IshiiM Tsuchiya
Oct 31, 2000·Phytotherapy Research : PTR·J EdwardsE Reyes
Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield

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