Significance of serum uric acid in pulmonary hypertension due to systemic sclerosis: a pilot study.

Rheumatology International
Theodoros DimitroulasLoukas Settas

Abstract

Systemic sclerosis is a connective tissue disease, which may lead to elevated pulmonary arterial pressure due to pulmonary arterial hypertension and/or left ventricular diastolic dysfunction. Uric acid (UA) has been shown to be elevated in patients with pulmonary hypertension (PH) and heart failure. We aimed to investigate the potent relationship between serum UA and pulmonary pressure as well as functional capacity in patients with SSc. We studied 66 patients (mean age 57.7±12.1years, 63 women), presenting with SSc. Systolic pulmonary artery pressure assessed by echocardiography, lung function tests, six-minute walk test (6MWT) and serum UA levels were recorded in all patients. In 24 (36%) patients, the diagnosis of PH was established by echocardiography (systolic pulmonary artery pressure ≥40 mmHg). Patients with PH had higher UA serum levels compared to patients without PH (5.1±2.1 mg/dl vs. 4.2±0.9 mg/dl, p=0.04). Among patients with PH, UA values were inversely correlated with the SMWT distance (r=-0.51, p=0.01). Serum UA values increased in proportion to the functional capacity in PH patients with scleroderma. Further investigations in prospective studies will unfold in detail the pathophysiological significance of UA in ...Continue Reading

References

Jan 14, 1999·European Heart Journal·F LeyvaA J Coats
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·N NagayaK Miyatake
Jan 13, 2000·Chest·M A VoelkelN F Voelkel
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
Feb 18, 2003·Respiratory Medicine·D BendayanM R Kramer
Nov 8, 2006·International Journal of Cardiology·Theodoros DimitroulasLoucas Settas
Mar 3, 2007·Annals of the Rheumatic Diseases·Virginia D Steen, Thomas A Medsger
Jul 27, 2007·Rheumatology International·Francesco De LeonardisFrancesco Trotta
Jun 19, 2008·European Journal of Heart Failure·Hernan AlcainoSergio Lavandero
Jul 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Roxana Sfrent-CornateanuElena Moldoveanu
Dec 3, 2008·Rheumatology International·Ismail SariNurullah Akkoc
Jan 9, 2009·Rheumatology International·Silvia A QuadrelliAlejandro Salvado
Feb 28, 2009·Rheumatology International·Sophie P Toya, George E Tzelepis
May 12, 2009·BMC Pulmonary Medicine·Andriana I PapaioannouZoe D Daniil
Jun 23, 2009·Seminars in Arthritis and Rheumatism·Theodoros DimitroulasLoucas Settas
Feb 16, 2010·Rheumatology International·Zaixing YangRenqian Zhong

❮ Previous
Next ❯

Citations

Mar 5, 2013·Rheumatology International·M P Cruz-DomínguezL J Jara
May 16, 2012·Heart Failure Reviews·Marc Kaufman, Maya Guglin
Mar 25, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Neeraj DhaunDavid J Webb
Apr 9, 2016·International Journal of Cardiology·Els VandecasteeleVanessa Smith
Jan 17, 2014·International Journal of Rheumatic Diseases·Ki-Jo KimChul-Soo Cho
Aug 8, 2015·Arthritis Research & Therapy·Zsuzsanna McMahanLaura K Hummers
Sep 8, 2016·Scandinavian Journal of Rheumatology·A NordinK Jensen-Urstad
Nov 14, 2012·Nature Reviews. Rheumatology·Zsuzsanna H McMahan, Laura K Hummers
Apr 25, 2018·The Journal of Dermatology·Yoshihide AsanoHironobu Ihn
Dec 21, 2019·European Heart Journal Supplements : Journal of the European Society of Cardiology·David G KielyMarc Humbert
Oct 31, 2013·Expert Review of Clinical Immunology·Flavia V Castelino, John Varga

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.