Significance of Simpson grading system in modern meningioma surgery: integration of the grade with MIB-1 labeling index as a key to predict the recurrence of WHO Grade I meningiomas

Journal of Neurosurgery
Soichi OyaNobuhito Saito

Abstract

Techniques for the surgical treatment of meningioma have undergone many improvements since Simpson established the neurosurgical dogma for meningioma surgery in his seminal paper published in 1957. This study aims to assess the clinical significance and limitations of the Simpson grading system in relation to modern surgery for WHO Grade I benign meningiomas and to explore the potential of the cell proliferation index to complement the limitations in predicting their recurrence. The surgical records of patients who underwent resection of intracranial meningiomas at the University of Tokyo Hospital between January 1995 and August 2010 were retrospectively analyzed. The authors investigated the relationships between recurrence-free survival (RFS) and Simpson grade or MIB-1 labeling index value. A total of 240 patients harboring 248 benign meningiomas were included in this study. Simpson Grade IV resection was associated with a significantly shorter RFS than Simpson Grade I, II, or III resection (p<0.001), while no statistically significant difference was noted in RFS between Simpson Grades I, II, and III. Among meningiomas treated by Simpson Grade II and III resections, however, multivariate analysis revealed that an MIB-1 index ...Continue Reading

References

Jan 1, 1975·Journal of Neurology·K Jellinger, F Slowik
Mar 1, 1979·Neurochirurgia·S MelamedA J Beller
Jan 1, 1990·Acta neurochirurgica·M Naumann, J Meixensberger
Jan 1, 1985·Journal of Neurosurgery·R O MirimanoffR L Martuza
Jan 1, 1974·Acta Neuropathologica·K Skullerud, A C Löken
Feb 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·M R Crompton, P C Gautier-Smith
Jan 1, 1983·Journal of Neurosurgery·A B AdegbiteL K Tan
Feb 1, 1994·Neurologia Medico-chirurgica·K KunishioA Nishimoto
Jul 1, 1993·Brain Pathology·P KleihuesB W Scheithauer
May 1, 1993·AJR. American Journal of Roentgenology·W L HirschC N Sen
Jul 1, 1996·Neurosurgery·T MathiesenB Karlsson
Mar 21, 2001·The American Journal of Surgical Pathology·S NakasuM Matsuda
Jun 2, 2001·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·L N SekharS Sarma
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Bruce E PollockShawn A Schreiner
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·D SIMPSON
Sep 26, 2003·Cancer·William M MendenhallWilliam A Friedman
Jan 24, 2004·Acta neurochirurgica·F RoserM Bellinzona
Jun 28, 2005·Journal of Neuro-oncology·Davide SchifferValentina Fiano
Sep 6, 2006·Neurosurgical Review·Hidetoshi KasuyaTomokatsu Hori
Jun 21, 2007·American Journal of Clinical Pathology·Yoo-Jin KimWolfgang Feiden
Nov 21, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Mahesha VankalakuntiVirender Kumar Khosla
Dec 12, 2007·British Journal of Neurosurgery·S J SmithD C Macarthur
Nov 4, 2008·Journal of Neurosurgery·Yoshiyasu IwaiHidetoshi Ikeda
Oct 27, 2009·Brain Tumor Pathology·Satoshi NakasuKazuhiko Nozaki
Apr 13, 2010·Journal of Neurosurgery·Roberto C Heros

❮ Previous
Next ❯

Citations

Sep 24, 2013·Journal of Neurosurgery·Roberto C Heros
Dec 3, 2013·Neurosurgical Focus·Elizabeth N KuhnStephen B Tatter
Dec 3, 2013·Neurosurgical Focus·Marcus D MazurPhilipp Taussky
Apr 27, 2013·Clinical Neuropathology·Anna S BerghoffUNKNOWN Vienna Comprehensive Cancer Center Central Nervous System Unit
Feb 28, 2014·Surgical Neurology International·Carlos Eduardo da SilvaJefferson Luis Braga da Silva
May 23, 2014·AJR. American Journal of Roentgenology·Yi TangDeepak Takhtani
Dec 31, 2015·Acta neurochirurgica·Hussam Abou Al-ShaarAmir R Dehdashti
Jan 30, 2016·Journal of Neurosurgery·Konstantinos GousiasMatthias Simon
Sep 9, 2015·Neurologia Medico-chirurgica·Masahiro ShinNobuhito Saito
May 2, 2015·Brain Tumor Pathology·Mario VenzaIsabella Venza
Jul 15, 2015·Surgical Neurology International·Carlos Eduardo da Silva, Paulo Eduardo Peixoto de Freitas
Apr 23, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sayaka YuzawaShinya Tanaka
Dec 17, 2014·Acta neurochirurgica·Kayvan D JadidTiit Mathiesen
Oct 25, 2014·Journal of Neurosurgery·Leland RogersMichael A Vogelbaum
Jul 28, 2016·Journal of Surgical Case Reports·Samuel DobrowolskiMarcos Tatagiba
Jul 29, 2016·Acta Neuropathologica·Peter BaumgartenPatrick N Harter
Sep 24, 2016·Journal of Neurosurgery·Soichi Oya
May 18, 2017·World Neurosurgery·Judith AnthoferKarl-Michael Schebesch
Aug 14, 2015·American Journal of Clinical Oncology·Yunseon ChoiHeerim Nam
Nov 17, 2017·Surgical Neurology International·Pablo AjlerClaudio Yampolsky
May 20, 2015·Veterinary and Comparative Oncology·J HicksA Haley
Aug 8, 2018·Future Oncology·Robin A BuerkiRimas V Lukas
Jun 7, 2017·Journal of Clinical Imaging Science·Eli TshibwabwaJenifer Cannon
Dec 5, 2017·Continuum : Lifelong Learning in Neurology·Roy E Strowd, Jaishri O Blakeley
Jul 22, 2014·Brain Pathology·Adriana OlarKenneth D Aldape
Sep 29, 2019·Current Treatment Options in Neurology·Michele BailoPietro Mortini
Jul 17, 2015·Neurosurgery·Laligam N SekharJames S Pridgeon
Dec 25, 2019·Acta neurochirurgica·Florian ScheichelFranz Marhold
Apr 22, 2020·British Journal of Neurosurgery·Francesco MaiuriOreste de Divitiis
Apr 30, 2020·Journal of Neurosurgical Sciences·Alexandre LavéMarco V Corniola
Aug 19, 2020·Neurosurgical Review·Benjamin BrokinkelWalter Stummer
Jun 1, 2016·Neuro-oncology Practice·Shannon E FoghPhilip V Theodosopoulos

❮ Previous
Next ❯

Software Mentioned

JMP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.