Significance of size of lymph node metastasis on postsurgical stimulated thyroglobulin levels after prophylactic unilateral central neck dissection in papillary thyroid carcinoma.

Annals of Surgical Oncology
Brian Hung-Hin LangChung-Yau Lo

Abstract

The prognostic significance of size of central lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC) remains unknown. Because postsurgical detectable stimulated thyroglobulin (DsTg) after radioiodine ablation may imply persistent or recurrent disease, we evaluated the association between size of CLNM and rate of DsTg in patients with PTC who underwent unilateral prophylactic central neck dissection. To be eligible for analysis, the prophylactic central neck dissection specimen with <3 central lymph nodes (CLNs) or size of CLNM ≥1 cm as measured under the microscope was excluded. Of 132 specimens, 89 (67.4%) were eligible. Forty patients (44.9%) had no metastasis or pN0, 20 (22.5%) had micrometastasis (<2 mm) or pN1mic and 29 (32.6%) had macrometastasis (≥2 mm) or pN1mac. Postablation sTg level was measured 9 months after surgery. A multivariable analysis was conducted to identify independent factors for postablation DsTg. Larger-sized CLNM correlated significantly with younger age (p = 0.028), greater number of CLN retrieved (p = 0.016), greater number of metastatic CLN excised (p < 0.001), higher metastatic CLN ratio (p = 0.006) and postablation sTg level (p = 0.012). In the multivariable analysis, after adjusting ...Continue Reading

References

Jun 22, 2005·Current Treatment Options in Oncology·Nadine R Caron, Orlo H Clark
Nov 15, 2006·Annals of Surgical Oncology·Brian Hung-Hin LangKoon-Yat Wan
Apr 17, 2007·Annals of Surgery·Brian Hung-Hin LangKoon-Yat Wan
Mar 26, 2008·European Journal of Endocrinology·Stéphane BardetMichel Henry-Amar
May 28, 2008·Surgical Oncology·Isaac M Cranshaw, Bruno Carnaille
Apr 8, 2009·Thyroid : Official Journal of the American Thyroid Association·Giuseppe MercanteVerter Barbieri
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle

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Citations

Jul 6, 2014·Clinical Endocrinology·Petros PerrosUNKNOWN British Thyroid Association
Aug 1, 2015·Archives of Pathology & Laboratory Medicine·Raja R SeethalaYuri E Nikiforov
Aug 1, 2015·Archives of Pathology & Laboratory Medicine·Rebecca D Chernock, James S Lewis
Aug 28, 2020·Revista do Colégio Brasileiro de Cirurgiões·RogÉrio Aparecido DedivitisSilvia Picado Petrarolha
Oct 17, 2015·ANZ Journal of Surgery·Carlos StephensonLeigh Delbridge

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BETA
dissection

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SPSS

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