Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer

World Journal of Gastroenterology : WJG
Hao DengLi-Jiang Liu

Abstract

To study the relationship between Survivin and PTEN expression and lymph node metastasis, depth of invasion and prognosis of gastric cancer patients in China. Specimens of gastric cancer tissue were collected from the Affiliated Hospital of Jianghan University. All the 140 patients had complete examination data. All lymph nodes were found by the fat-clearing method. The interrupted serial 4-micron sections, routine hematoxylin and eosin staining and immunohistochemical methods were used to detect the lymph node metastases. Gastric cancer tissue microarray was performed to test the expression of Survivin and PTEN (17A) in gastric cancer by immunohistochemical method. All data were processed using chi2 test, Fisher's exact test, Kaplan-Meyer Log-rank method and Cox multivariate analysis (SPSS 12.0 software). One hundred and eighteen specimens were used in our tissue microarray (utilization rate was 82.4%). A total of 7580 lymph nodes were found. Metastases were found in 90 specimens and 1618 lymph nodes were detected. The positive rate of Survivin and PTEN expression was 52.5% (62/118) and 76.2% (90/118), respectively. A highly positive correlation was found between Survivin and PTEN expression (chi2 = 4.17, P = 0.04). Survivin e...Continue Reading

References

Aug 1, 1997·Nature Medicine·G AmbrosiniD C Altieri
Aug 7, 1999·The New England Journal of Medicine·H S SwanaD C Altieri
Sep 1, 1999·European Journal of Biochemistry·A BessonV W Yong
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MonzóA Abad
Jun 8, 2001·Annual Review of Biochemistry·T MaehamaJ E Dixon
Mar 5, 2002·American Journal of Human Genetics·Kristin A Waite, Charis Eng
Oct 1, 2004·World Journal of Gastroenterology : WJG·Zhen-Ning WangXue Zhang

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Citations

Aug 21, 2013·Molecular Biology Reports·Andreas KriegWolfram Trudo Knoefel
Jan 24, 2007·Journal of Cellular Physiology·Paraskevi VogiatziAntonio Giordano
Dec 20, 2012·Experimental and Therapeutic Medicine·Xuehua ZhuCrystal Ying Qin

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