PMID: 7545144Feb 20, 1995Paper

Significance of tenascin serum level as tumor marker in primary colorectal carcinoma

International Journal of Cancer. Journal International Du Cancer
S RiedlA Faissner

Abstract

Tenascin serum levels were evaluated in 118 patients with primary colorectal carcinoma and in a control group of 51 healthy persons in a double-sided sandwich ELISA. The data were correlated with post-operative TNM-staging. Patients with colorectal carcinomas had significantly higher serum levels of tenascin than the control group. At the 95% level of specificity, sensitivity was 25%. Tumor grading obviously had no influence on the level of tenascin in serum. With increasing pT-category, tenascin levels increased as well. In patients with distant metastatic disease, serum tenascin levels were significantly higher than in patients without distant metastases. These data suggest that, in colorectal carcinoma, the preoperative level of serum tenasin reflects the total tumor burden and correlates with metastatic disease. Our observation warrants a prospective study of the relevance of tenascin serum levels with regard to prognosis and as an indicator of relapse.

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Citations

Jul 15, 1999·International Journal of Cancer. Journal International Du Cancer·M DueckA Faissner
Sep 29, 1995·Experientia·R Chiquet-Ehrismann
Mar 24, 1998·Diseases of the Colon and Rectum·S RiedlA Faissner
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