PMID: 11920609Mar 29, 2002Paper

Significance of the association between heparin-binding epidermal growth factor-like growth factor and CD9 in human gastric cancer

International Journal of Cancer. Journal International Du Cancer
Yoko MurayamaYuji Matsuzawa

Abstract

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family. Juxtacrine activity of proHB-EGF (the membrane-anchored form of HB-EGF) has been shown to be significantly potentiated when it is coexpressed with CD9 in vitro. The purpose of our study was to investigate the issue of whether proHB-EGF and CD9 are coexpressed in gastric cancer. HB-EGF gene expression and protein production in human gastric cancers was investigated, and EGF receptor and CD9 expressions were also evaluated. HB-EGF mRNA levels in gastric cancers were elevated, compared with normal gastric tissues, especially in the intestinal type. ProHB-EGF immunoreactivity was detected primarily in the cytoplasm and plasma membrane of gastric cancer cells. Of 66 patients, 40 (60.6%) exhibited proHB-EGF immunoreactivity and the level of its expression was significantly associated with tumor status (p < 0.01) and histological differentiation (p < 0.001). In addition, proHB-EGF mRNA was detected at high levels in the intestinal type by in situ hybridization. CD9 immunoreactivity was found to be preserved in 26 of 36 patients (72.2%) and CD9 protein expression was inversely associated with lymph node status (p < 0.05). A significant co...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Aug 30, 1991·Biochemical and Biophysical Research Communications·J G Seehafer, A R Shaw
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·E Tahara
Apr 1, 1990·Gastroenterology·A PfeifferK Mann
Mar 17, 1988·Nature·M B Sporn, A B Roberts
Feb 6, 1985·Nature·M B Sporn, A B Roberts
Aug 15, 1994·Biochemical and Biophysical Research Communications·M S KobrinM Korc
Jan 14, 1994·Biochemical and Biophysical Research Communications·N ItoY Matsuzawa
Aug 1, 1993·Japanese Journal of Cancer Research : Gann·Y KitadaiE Tahara
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M MarikovskyM Klagsbrun
May 3, 1996·International Journal of Cancer. Journal International Du Cancer·M NaefM Korc
Jun 5, 1996·Biochemical and Biophysical Research Communications·Y MiyazakiY Matsuzawa
Oct 9, 1996·International Journal of Cancer. Journal International Du Cancer·E MiyoshiN Taniguchi
Apr 22, 1997·International Journal of Cancer. Journal International Du Cancer·M HigashiyamaM Miyake
Mar 21, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D J Riese, D F Stern
Oct 7, 1998·International Journal of Cancer. Journal International Du Cancer·M ShoM Miyake

❮ Previous
Next ❯

Citations

Dec 25, 2010·Clinical & Experimental Metastasis·Mekel M RichardsonXin A Zhang
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gavin J GordonRaphael Bueno
Apr 7, 2005·Digestive Diseases·A LeodolterP Malfertheiner
Dec 24, 2013·World Journal of Gastroenterology : WJG·Samantha Shi Min LingBow Ho
May 27, 2009·Journal of Gastroenterology·Taisei NakamotoNorio Hayashi
Mar 12, 2015·Molecular Medicine Reports·Gong-Ping Wang, Xiao-Fang Han
Sep 1, 2005·International Journal of Andrology·Y ChuanA Pousette
Oct 13, 2010·The Journal of Pathology·Hanna M Romanska, Fedor Berditchevski
Feb 11, 2014·International Journal of Cancer. Journal International Du Cancer·Soichiro SasakiNaofumi Mukaida
Mar 30, 2004·The Journal of Surgical Research·Haruko HoriKazuo Shirouzu
Feb 6, 2008·Journal of Cellular Physiology·Yoko MurayamaNorio Hayashi
Jul 30, 2005·International Journal of Cancer. Journal International Du Cancer·Takashi OhtsukaYasunori Okada
Dec 10, 2016·Journal of Cancer Research and Clinical Oncology·Julia KneisslBirgit Luber
Feb 27, 2015·World Journal of Gastroenterology : WJG·Hye Won ChungJong-Baeck Lim
Mar 26, 2015·World Journal of Gastroenterology : WJG·Yoko MurayamaShusaku Tsutsui
Jul 30, 2018·Investigational New Drugs·Kathleen N MooreGiorgio Senaldi
Sep 16, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shingo MiyamotoEisuke Mekada
Aug 4, 2004·Cancer Research·Pat P OngusahaSam W Lee
Jul 1, 2004·Journal of Cell Science·Yoko MurayamaYasuhisa Shinomura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.