PMID: 9166987Apr 1, 1997Paper

Significance of the DNA synthesis in hypertrophic cardiomyopathies

Basic Research in Cardiology
Luigi MatturriL Rossi

Abstract

DNA content and proliferating cell nuclear antigen (PCNA) expression were investigated in normal hearts, in hypertrophic from hemodynamic overload hearts and in hypertrophic cardiomyopathy (HCM). The aim of this study was mainly to determine whether the hyperdiploid myocardial cells in all cases are in dynamic or static phase. The percentage of PCNA positive cells only in the HCM group was significantly higher (mean value = 25.4%) than the percentage of hyperdiploid cells (mean value = 9.3%). Therefore, the DNA replication occurs through a different process from that of normal cell cycle which lead to an increase in ploidy and eventually mitosis. These data should be interpreted not only as the result of a periodic amitotic DNA renewal and not even as the result of an increased apoptosis, but especially as a repair process of the DNA molecules affected by a various types of damages in HCMs.

References

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Citations

Jun 11, 2004·Genome Génome / Conseil National De Recherches Canada·Olga V Anatskaya, Alexander E Vinogradov
Mar 17, 2007·Journal of Molecular and Cellular Cardiology·Katrina A BicknellGavin Brooks
May 3, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Hernán García-RivelloCecilia M Hertig

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