Significance of the Extracapsular Spread of Metastatic Lymph Nodes in Papillary Thyroid Carcinoma

Clinical and Experimental Otorhinolaryngology
Chang Ho ParkKyung Tae

Abstract

The extracapsular spread (ECS) of metastatic lymph nodes is associated with aggressive tumor behavior, and is regarded as a major risk factor for local recurrence in patients with head and neck squamous cell carcinoma. However, the significance of ECS of metastatic lymph nodes has not been well established in well-differentiated thyroid carcinoma. The purpose of this study was to examine this question. A retrospective review was performed of 335 patients with papillary thyroid carcinoma who underwent total thyroidectomy with lymph node dissection from April 2001 to December 2009. We analyzed various clinical characteristics, pathologic factors, and the size, number, and ECS of foci in metastatic lymph nodes. On pathologic review, 201 of the patients (56.6%) had lymph node metastasis. This was significantly related to age and tumor size. ECS was noted in 64 of these 201 patients (31.8%), and was significantly related to male gender, tumor size, presence of extrathyroidal extension, metastatic lymph node size, and focus size. Recurrence occurred in 13 patients (3.9%), and the presence of ECS was significantly related to recurrence. ECS of metastatic lymph nodes is an important prognostic factor for loco-regional recurrence in pap...Continue Reading

References

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Citations

Jan 14, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hyoung Shin LeeKang Dae Lee
Aug 16, 2016·Clinical and Experimental Otorhinolaryngology·Yong Bae JiKyung Tae
Aug 20, 2017·Annals of Surgical Oncology·Yehree KimSang Yoon Kim
Nov 10, 2017·Thyroid : Official Journal of the American Thyroid Association·Sung Hoon NamSang Yoon Kim
Sep 4, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Suvi RenkonenKatri Aro
Jun 1, 2020·The Journal of Clinical Endocrinology and Metabolism·Seung-Nam JungBon Seok Koo
Dec 22, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ahmad M EweidaAman S Nabawi
Dec 16, 2020·The Laryngoscope·Stefano TaboniDavide Lombardi
Sep 20, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Priyanka Bhattacharya, Rajarshi Mukherjee
Jul 5, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Julia E NoelLisa A Orloff

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