Significance of the number of high-risk factors in patients with cervical cancer treated with radical hysterectomy and concurrent chemoradiotherapy

Gynecologic Oncology
Hakyoung KimWon Park

Abstract

The purpose of this study was to evaluate the impact of high-risk factors on the survival of patients with cervical cancer treated with surgery followed by adjuvant chemoradiotherapy. From 2000 to 2014, medical records of 897 patients with International Federation of Gynecology and Obstetrics stage IB-IIA disease treated with surgery were retrospectively reviewed. Among them, 483 patients with high-risk factors, including pelvic lymph node metastasis, parametrial invasion, or resection margin involvement, were analyzed. The median follow-up time was 57 months (range, 6-205 months). For patients with single and multiple high-risk factors, the 5-year DFS rates were 80.4% and 65.7%, respectively (p < 0.001), and 5-year OS rates were 87.3% and 75.1%, respectively (p = 0.001). Distant metastasis was the most common pattern of recurrence (86.1%). Furthermore, distant metastasis-free survival significantly differed with the number of high-risk factors present (single 82.7% vs. multiple 68.8%, p < 0.001). In the multivariate analysis, while parametrial invasion and resection margin involvement showed no association, the adenocarcinoma histology, pelvic lymph node metastasis, higher metastatic lymph node ratio, and multiple high-risk fa...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·H FagundesM A Lockett
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Jul 5, 2003·Lancet·Steven E Waggoner
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patricia J EifelDavid G Mutch
Apr 22, 2004·Gynecologic Oncology·Laura J HavrileskyAngeles Alvarez Secord
Nov 16, 2010·International Journal of Radiation Oncology, Biology, Physics·Chel Hun ChoiByoung-Gie Kim
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Jun 10, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hyoung Uk JeJoo-Young Kim
Oct 14, 2014·Journal of Gynecologic Oncology·Koji MatsuoTadashi Kimura
Dec 9, 2016·Radiation Oncology Journal·Kyungmi YangJeong-Won Lee
Jan 12, 2019·Radiation Oncology Journal·Oyeon Cho, Mison Chun

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