Significance of the vascular endothelial growth factor and the macrophage migration inhibitory factor in the progression of hepatocellular carcinoma

Oncology Reports
Dong WangXiao-Hui Huang

Abstract

The aim of the present study was to investigate the expression of vascular endothelial growth factor (VEGF) and macrophage migration inhibitory factor (MIF) in HCC progression and their correlation with clinicopathological factors as well as the relationship between their expression levels. The expression of serum VEGF and MIF was evaluated in 150 patients with HCC and in 30 normal volunteers by enzyme-linked immunosorbent assay (ELISA). VEGF and MIF expression levels were evaluated by immunohistochemistry on tissue microarrays containing 150 HCCs with paired adjacent non-cancer liver tissues. VEGF and MIF mRNA levels were determined by quantitative PCR in another 48 HCCs. The correlation of VEGF and MIF with clinicopathological factors was analyzed in HCC. Serum VEGF and MIF concentrations were higher in HCC patients than the levels in the controls. The expression levels of VEGF and MIF in the HCC tissues were both higher than those in the adjacent non-tumor liver tissues. Overexpression of VEGF and MIF was significantly associated with tumor size (P=0.027 and 0.022, respectively), intrahepatic metastasis (P=0.032 and 0.027, respectively), vascular invasion (P=0.044 and 0.039, respectively) and TNM stage (P=0.028 and 0.013, re...Continue Reading

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Citations

Aug 13, 2015·PloS One·Gary A ClawsonThomas Abraham
Aug 25, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·André C TeixeiraFabio Tavora
Oct 24, 2017·International Journal of Immunogenetics·M QrafliK Sadki
Sep 29, 2015·International Journal of Oncology·Vincent RichardSven Saussez
Jan 9, 2021·BMC Cancer·Martha M GrimesLaurie G Hudson

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