Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma

Journal of Thyroid Research
Toral P KobawalaNandita R Ghosh

Abstract

Circulating levels of TNF-α and the adhesion molecules L-Selectin and VCAM-1 as well as their expression in the primary tumors of patients with benign thyroid diseases and papillary thyroid carcinoma (PTC) have been determined in this study. The serum levels of TNF-α, L-Selectin, and VCAM-1 were significantly higher in patients with both benign thyroid diseases and PTC as compared to the healthy individuals. However, the levels of only TNF-α and L-Selectin, and not VCAM-1, were significantly higher in patients with PTC in comparison to those observed in patients with benign thyroid diseases. Further the expression of TNF-α and L-Selectin was also significantly higher in the primary tumors of PTC patients, relative to the benign thyroid diseases. The expression of L-Selectin and VCAM-1 significantly correlated with aggressive tumor behavior. In PTC patients, the circulating TNF-α levels significantly positively correlated with the levels of L-Selectin, while TNF-α immunoreactivity was significantly associated with VCAM-1 expression. Serum TNF-α was found to be a significant prognosticator for OS in PTC patients. Overall the results signify that the interaction between TNF-α and the adhesion molecules may have a role in thyroid c...Continue Reading

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Citations

Apr 2, 2016·Journal of Thyroid Research·Toral P KobawalaNandita R Ghosh
Feb 29, 2020·Journal of Lower Genital Tract Disease·Fatma Faisal DarweeshAhmed A Metwally
Aug 5, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Carla Fernanda NavaJose Miguel Dora
Aug 23, 2019·Medicina·Mihai SaftencuIoana Berindan-Neagoe

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Software Mentioned

GLOBOCAN
Statistical Package for Social Sciences ( SPSS )
GraphPad Prism

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