PMID: 8606270Mar 1, 1996Paper

Significance of transient ST-T segment changes during dobutamine testing in Q wave myocardial infarction

Journal of the American College of Cardiology
A LombardoA Maseri

Abstract

We evaluated dobutamine stress electrocardiography for detecting potentially reversible contractile dysfunction or residual ischemia in the infarct-related area. ST-T segment changes in pathologic Q wave leads during stress testing may reflect contractile reserve, inducible ischemia or passive mechanical stretching. Dobutamine echocardiography allows detection of contractile reserve at low doses and inducible ischemia at high doses. We used low (5 to 10 microg/kg body weight per min) and high doses (20 to 40 microg/kg per min) of dobutamine in 49 patients with a previous Q wave myocardial infarction and analyzed the relation between ST-T segment changes in pathologic Q wave leads and regional contraction. At low dose dobutamine, regional contraction improved in the infarct-related area in 23 patients. New or further ST segment elevation and pseudonormalization of negative T waves developed at low doses more frequently in patients with than without contractile reserve (both p < 0.001), giving a sensitivity of 43.5% and 60.9% and a specificity of 100% and 96.2%, respectively. At high dose dobutamine (43 patients), new or further ST segment elevation and pseudonormalization of negative T waves, occurring beyond those observed at l...Continue Reading

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Citations

Mar 10, 1999·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·A GiorgettiO Parodi
Mar 1, 2006·American Heart Journal·Ana Lucia M ArrudaPatricia A Pellikka
Jul 9, 2005·Journal of Electrocardiology·Jaume FiguerasJordi Soler Soler
Nov 1, 2007·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Fabio InfusinoFilippo Crea
Feb 19, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Masakazu YamagishiUNKNOWN Japanese Circulation Society Working Group

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