Significance of Trask protein interactions in brain metastatic cohorts of lung cancers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Hua WuGang Sun

Abstract

A class of adhesion protein that occurs in the membrane with both extracellular and intracellular domain and play vital role in maintaining multicellularity is TRASK, also called CUB-domain containing protein1, CD318 (CDCP1). Specifically, in the current study, documented aggressive grades of lung cancers and distant metastatic tissues were examined for protein interactions of Trask and compared with lung cancer variants in situ. The intracellular domain of Trask has the ability to undergo tyrosine phosphorylation and thereafter undergo increased genomic expression, as well as interact with cytoskeletal proteins in the cell periphery and other local signal transduction machinery to induce invadopodia formation and distant metastasis. We incorporated proximity ligation assay to examine protein interactions of Trask in metastatic lung cancer tissues and compare with advanced and low-grade lung cancers restricted to the primary site of origins. Here, we provide direct evidence that activated Trask, which is a phosphorylated form, binds with cytoskeletal proteins actin and spectrin. These interactions were not seen in locally growing lung cancer and cancer in situ. These interactions may be responsible for invadopodia formation and...Continue Reading

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Citations

Apr 15, 2016·Biomolecular Detection and Quantification·Christina GreenwoodStephen A Bustin
Sep 13, 2016·International Journal of Molecular Sciences·Lukas KlumppStephan M Huber

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