Significance of trisomy 7 related to PCNA index in cholesteatoma

American Journal of Otolaryngology
A LavezziL Matturri

Abstract

To define the biological features of the variable aggressiveness of cholesteatoma, we performed a retrospective cytogenetic and kinetic study. We studied 44 cases of cholesteatoma by using fluorescence in situ hybridization with specific alpha-satellite DNA probes for chromosome 7 and immunohistochemical analysis of proliferating cell nuclear antigen (PCNA) with PC10 monoclonal antibody. We observed the presence of three or four chromosome 7 in elevated percentages of cells of 23 cases, and a high PCNA index (above mean value) in 22 cases. Based on our results, we maintain that the presence of an extra chromosome 7 is correlated with an increase of proliferative activity. Therefore, trisomy 7 can be considered a prognostic marker and an indicator of aggressive behavior in cholesteatoma.

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Citations

Jun 19, 2001·The Laryngoscope·Y A BayazítM Kanlíkama
Jun 2, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hans-J WelkoborskyMike L Hinni
Nov 6, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Szilvia EcsediMargit Balázs
Oct 23, 2002·The Annals of Otology, Rhinology, and Laryngology·Shin-ichi HaginomoriIsamu Sando
Jul 11, 2008·Acta Oto-laryngologica·Tae Young Yune, Jae Yong Byun

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