Significance of UGT1A1 *28 Genotype in Patients with Advanced Liver Injury Caused By Chronic Hepatitis C

Journal of Medical Biochemistry
Jelena JordovicDragan Delic

Abstract

Chronic hepatitis C (CHC) is a significant cause of liver related morbidity and mortality worldwide. The role of genetics in the host response to hepatitis C virus is not elucidated. Genetic variations in UGT1A1 gene are the most common cause of hereditary unconjugated hyperbilirubinemia-Gilbert syndrome. This is the first study investigating the association of UGT1A1 TA repeats promoter genotypes with the degree of liver injury, viremia and biochemical markers in CHC patients with advanced liver injury and late virological relapse. Genetic testing of UGT1A1 TA repeats promoter genotypes was performed in 42 CHC patients with advanced fibrosis and cirrhosis who achieved sustained virological response and 42 healthy blood donors. CHC patients were evaluated for clinical findings, laboratory tests and imaging. UGT1A1*28 genotype (7/7 TA repeats) was observed in 23.8% CHC patients and 16.7% healthy controls with no significant difference in genotype frequencies (p=0.49). Pretreatment levels of ferritin and bilirubin were associated with the presence of UGT1A1*28 genotype, indicating its potential as a predictive marker. However, in our study, there was no correlation of UGT1A1*28 genotype with the degree of fibrosis or viremia. Dur...Continue Reading

References

Jun 1, 1975·Journal of Medical Genetics·D Owens, J Evans
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·E BeutlerA Demina
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·S M HarmanUNKNOWN Baltimore Longitudinal Study of Aging
Feb 15, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P S KamathW R Kim
Aug 10, 2005·The American Journal of Gastroenterology·Chien-Sen TsengChing-Shan Huang
Oct 7, 2006·Annals of Clinical Biochemistry·G M Hirschfield, G J Alexander
Jan 19, 2007·World Journal of Gastroenterology : WJG·Neda SvirtlihVladimir Urban
Feb 19, 2008·Journal of Hepatology·Ariane MallatSophie Lotersztajn
Jun 5, 2010·Advances in Clinical Chemistry·Massimo FranchiniGiuseppe Lippi
Jan 29, 2011·Applied Health Economics and Health Policy·Paul BrownJane Willingale
Feb 22, 2011·Radiologic Clinics of North America·Alexander DingPari V Pandharipande
Nov 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hamish A InnesUNKNOWN Hepatitis C Clinical Database Monitoring Committee
Feb 28, 2014·World Journal of Hepatology·Linda PiekuseAstrida Krumina
Jan 5, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Lawrence Serfaty
Jan 21, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bryony SimmonsGraham S Cooke
Jul 7, 2017·Journal of Medical Biochemistry·Giuseppe LippiMario Plebani

❮ Previous
Next ❯

Citations

Dec 4, 2020·Journal of Medical Biochemistry·Milica ĆulafićĐorđe Ćulafić

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR
biopsies

Software Mentioned

Statistical Package for Social Sciences ( SPSS®

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
Amna Subhan ButtWasim Jafri
JAMA : the Journal of the American Medical Association
Patrick Maisonneuve, Savino Bruno
Liver International : Official Journal of the International Association for the Study of the Liver
Ehsaan AkhtarSammy Saab
© 2022 Meta ULC. All rights reserved