Abstract
To elucidate the association between clinical characteristics and immuno-phenotypes in patients with ANCA-associated vasculitis (AAV). Peripheral blood from 36 patients with active AAV and 18 healthy controls was examined for numbers of circulating T cells, B cells, NK cells, dendritic cells, monocytes and granulocytes using flow cytometry. These immuno-phenotyping data were subjected to cluster analysis and principal components analysis to divide AAV patients into subgroups. Associated organ involvement or therapeutic prognosis were assessed for each subgroup. AAV patients had higher proportions of plasma cells, plasmablasts, activated T cells, CD14++ CD16+ monocytes, eosinophils and neutrophils than healthy controls. Immuno-phenotyping findings were similar between patients with microscopic polyangiitis, granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis. Cluster analysis indicated that AAV patients could be divided into three subgroups according to peripheral immune cell numbers: antibody production-related (n = 9), cytotoxic activity-related (n = 4) and neutrocytosis/lymphocytopenia-related (n = 23). The antibody production-related or cytotoxic activity-related group was associated with CNS i...Continue Reading
References
Nov 1, 1973·Medicine·A S Fauci, S M Wolff
Feb 1, 1994·Arthritis and Rheumatism·J C JennetteC G Kallenberg
Aug 12, 2006·Annals of the Rheumatic Diseases·Richard WattsDavid Scott
Jun 26, 2008·Arthritis and Rheumatism·Wayel H AbdulahadCees G M Kallenberg
Jul 22, 2010·The New England Journal of Medicine·Rachel B JonesUNKNOWN European Vasculitis Study Group
Jul 22, 2010·The New England Journal of Medicine·John H StoneUNKNOWN RAVE-ITN Research Group
Nov 27, 2010·Annals of the Rheumatic Diseases·Oliver FlossmannUNKNOWN European Vasculitis Study Group
Feb 22, 2012·Nature Reviews. Immunology·Holden T MaeckerRobert Nussenblatt
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Jun 27, 2013·Arthritis Research & Therapy·Wayel H AbdulahadPeter Heeringa
Nov 26, 2013·Brain : a Journal of Neurology·Akiko YokosekiIzumi Kawachi
Dec 21, 2013·Rheumatology·Yuan ZhaoDavid P D'Cruz
Apr 5, 2016·Cell·Romain BanchereauVirginia Pascual
Apr 13, 2017·Journal of the American Society of Nephrology : JASN·David R W JayneUNKNOWN CLEAR Study Group
Jun 13, 2017·Arthritis & Rheumatology·Satoshi KuboYoshiya Tanaka
Oct 19, 2017·Rheumatology·Kornelis S M van der GeestAbraham Rutgers
Apr 29, 2018·Medicine·Kotaro MatsumotoTsutomu Takeuchi
Jun 26, 2018·Arthritis & Rheumatology·Daniel Toro-DomínguezMarta E Alarcón-Riquelme
Jun 29, 2018·Annals of the Rheumatic Diseases·Andreas KronbichlerDavid R W Jayne
Citations
Jan 1, 2020·Arthritis Research & Therapy·Kotaro MatsumotoTsutomu Takeuchi
Jan 10, 2021·Scientific Reports·Kotaro MatsumotoTsutomu Takeuchi
Dec 15, 2020·Journal of Immunology Research·Evelina ElmérÅsa C M Johansson
May 8, 2021·Arthritis Research & Therapy·Kotaro MatsumotoTsutomu Takeuchi