Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases

Journal of Human Genetics
Kosuke TanakaFumihiko Matsuda

Abstract

Although the association between CYP3A5 polymorphism and blood concentration of tacrolimus (TAC) in patients with solid organ transplantation was established, whether the association is also true in patients with connective tissue disease (CTD) who usually receive small amount of TAC is uncertain. Here, we performed a quantitative linear regression analysis to address the association between CYP3A5 and blood TAC concentration in patients with CTD. A total of 72 patients with CTD were recruited in the current study and genotyped for rs776746 in CYP3A5, which showed strong association with TAC concentration in patients with solid organ transplantation. The blood trough concentration of TAC after taking 3 mg per day was retrospectively obtained for each patient. As a result, allele A of rs776746 showed a significant association with a decreasing blood concentration of TAC (P=0.0038). Those who are carrying at least one copy of the A allele displayed decreased mean concentration of TAC by 31.0% compared with subjects with GG genotype. Rs776746 is associated with concentrations of TAC in patients with CTD.

References

Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Jan 26, 2010·Journal of Clinical Pharmacology·Shigeru MarubashiMasaki Mori
Dec 29, 2010·Modern Rheumatology·Satoshi TakahashiYoshihisa Nojima
Jun 8, 2013·Therapeutic Drug Monitoring·Ramin VafadariTeun van Gelder

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Citations

Aug 5, 2018·The Journal of Pharmacology and Experimental Therapeutics·Daniel P HeruthShui Qing Ye
Oct 11, 2014·Expert Review of Clinical Pharmacology·Karolína HronováOndřej Slanař

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