Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis

The Eurasian Journal of Medicine
Vural Taner YilmazRamazan Cetinkaya

Abstract

Von Willebrand factor (vWF) is a mediator that increases endotoxemic medium like in cirrhosis. In this study we evaluated the association of serum VWF antigen (Ag) level with the stage of cirrhosis (according to Child-Pugh classification). We included 82 cirrhotic patients (Female/Male (F/M): 26/56) and 86 healthy subjects (F/M: 44/42) in the study. Ages of the both groups of patients were not different (P= 0.095). We excluded possible other reasons that may cause VWF level increase. Diagnosis of cirrhosis was made on the basis of biopsy in 7 patients and with clinical and laboratory parameters in 75 patients. VWF Ag level was determined by immunoturbidimetric test. The stage of cirrhosis was defined with Child-Pugh classification. Data were analysed by using Statistical Package for the Social Sciences (SPSS) 10.0 software program. VWF Ag level was significantly higher in cirrhotic patients compared to control group (220±90 and 87±38, P<0.001, respectively). We observed significant increase of VWF Ag level with the increasing stages of cirrhosis according to Child-Pugh score (VWF Ag level for Child A-B-C 156.4±54/215±45/284.8±93, respectively; P values for Child A-B/A-C/B-C; <0.001/<0.001/0.006, respectively). Serum VWF Ag leve...Continue Reading

Citations

Oct 4, 2018·European Journal of Gastroenterology & Hepatology·Elsaed H IbrahimTarek M Taher
Apr 27, 2021·The Journal of Small Animal Practice·A WilkinsonD McClendon
Aug 10, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ankur Jindal
Apr 1, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick StarlingerJulie Heimbach

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