Significant association of HLA-DQ5 with autoimmune hepatitis in Taiwan

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Lok-Beng KoayChing-Yih Lin

Abstract

Genetic predisposition is known to be an important etiopathogenic factor of autoimmune hepatitis (AIH). HLA antigens associated with AIH have been well studied in Western countries and Japan, but there is no HLA typing data of AIH patients in Taiwan. We therefore investigated HLA phenotypes and their association with AIH patients and compared the results with those of normal subjects and patients with chronic liver disease. Group 1 consisted of 22 AIH patients. All were born in Taiwan with no history of blood transfusion. Group 2 consisted of 19 chronic liver disease patients. Group 3 consisted of 81 unrelated healthy subjects who were normal blood donors. All three groups were tested for HLA phenotypes (HLAA, B, C, DR, DQ) using the polymerase chain reaction-sequence specific probe method. The statistical method used was Fisher's exact test. We found that HLA-DQ5 was significantly more frequent in the AIH group compared to the control group (RR, 2.03; p = 0.034). Low frequency of A1 (n = 2/22), B8 (n = 1/22) and DR3 (n = 0/22) were noted compared to results from the West; only HLA-DR4 showed a higher rate in our AIH patients (n = 8/22). This is a preliminary report of our study of HLA antigens in AIH patients. Further investig...Continue Reading

References

Apr 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P T DonaldsonR Williams
Nov 1, 1993·Gastroenterology·A J CzajaS B Moore
Jul 22, 1998·Journal of Hepatology·M N Vázquez-GarcíaC Gorodezky
Jul 29, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I G McFarlane
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PandoL Fainboim
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L FainboimM Zelazko
Oct 5, 2002·Clinics in Liver Disease·Kirsten Muri Boberg
Oct 5, 2002·Clinics in Liver Disease·Peter T Donaldson, Albert J Czaja
Mar 15, 2005·Journal of Hepatology·Kaname YoshizawaKendo Kiyosawa

❮ Previous
Next ❯

Citations

Mar 27, 2018·Journal of Clinical and Translational Hepatology·Qi-Xia WangXiong Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.