Significant Association of Slow Vasogenic ICP Waves with Normal Pressure Hydrocephalus Diagnosis

Acta Neurochirurgica. Supplement
Andreas SpiegelbergVartan Kurtcuoglu

Abstract

We aimed to test whether there is an association of slow vasogenic wave (SVW) occurrence with positive response to external lumbar drainage (ELD) and ventriculoperitoneal shunting and to design a method for the recognition and quantification of SVWs in the intracranial pressure (ICP) signal. We constructed SVW templates using normalized sine waves. We calculated the cross-correlation between the respective SVW template and the ICP signal. This was followed by shifting the templates forward and performing the cross-correlation analysis again until the end of the recording. Cross-correlation values above a threshold were considered to be indicative of SVWs. This threshold was previously determined and validated on a sample of ICP records of six patients. We calculated the root mean square of the recognized SVW periods as a measure of signal strength. Time-averaged signal strength was calculated over the full recording time (ICPSmean) and over the wave periods (ICPS). We determined ICPS and ICPSmean in recordings of 2 groups of patients presenting with Hakim's triad: 26 normal pressure hydrocephalus (NPH) patients and 20 non-NPH patients. We then tested whether there was an association between ICPS or ICPSmean and the respective d...Continue Reading

Citations

Sep 10, 2019·Asian Journal of Neurosurgery·Boon Seng LiewBalamurugan Mangaleswaran
Dec 18, 2019·Acta neurochirurgica·Erta BeqiriPeter Smielewski
Oct 16, 2019·Fluids and Barriers of the CNS·Isabel Martinez-TejadaMorten Andresen
Oct 7, 2020·Physiological Measurement·Andreas SpiegelbergVartan Kurtcuoglu
Aug 28, 2021·Computer Methods and Programs in Biomedicine·Juanjo Pérez-SánchezAmbrosio Toval

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