Significant bone microarchitecture impairment in premenopausal women with active celiac disease

Bone
Maria Belen ZanchettaJulio César Bai

Abstract

Patients with active celiac disease (CD) are more likely to have osteoporosis and increased risk of fractures. High-resolution peripheral quantitative computed tomography (HR-pQCT) permits three-dimensional exploration of bone microarchitectural characteristics measuring separately cortical and trabecular compartments, and giving a more profound insight into bone disease pathophysiology and fracture. We aimed to determine the volumetric and microarchitectural characteristics of peripheral bones-distal radius and tibia-in an adult premenopausal cohort with active CD assessed at diagnosis. We prospectively enrolled 31 consecutive premenopausal women with newly diagnosed CD (median age 29 years, range: 18-49) and 22 healthy women of similar age (median age 30 years, range 21-41) and body mass index. Compared with controls, peripheral bones of CD patients were significantly lower in terms of total volumetric density mg/cm(3) (mean ± SD: 274.7 ± 51.7 vs. 324.7 ± 45.8, p 0.0006 at the radius; 264.4 ± 48.7 vs. 307 ± 40.7, p 0.002 at the tibia), trabecular density mg/cm(3) (118.6 ± 31.5 vs. 161.9 ± 33.6, p<0.0001 at the radius; 127.9 ± 28.7 vs. 157.6 ± 15.6, p < 0.0001 at the tibia); bone volume/trabecular volume ratio % (9.9 ± 2.6 vs....Continue Reading

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Citations

Feb 15, 2016·Current Osteoporosis Reports·María Belén ZanchettaJulio César Bai
Sep 28, 2016·Journal of Osteoporosis·Michael W J DavieChristopher A Sharp
Jul 23, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·María Belén ZanchettaJulio César Bai
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Oct 24, 2018·Current Osteoporosis Reports·Haley M ZylberbergPeter H R Green
Apr 17, 2021·Journal of the Endocrine Society·Maria Florencia SciosciaMaría Belén Zanchetta
May 6, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·María Belén ZanchettaJosé Rubén Zanchetta
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