Significant decline in lymphatic filariasis associated with nationwide scale-up of insecticide-treated nets in Zambia

Parasite Epidemiology and Control
M Nsakashalo-SenkweL A Kelly-Hope

Abstract

Lymphatic filariasis (LF) is a mosquito-borne disease, broadly endemic in Zambia, and is targeted for elimination by mass drug administration (MDA) of albendazole and diethylcarbamazine citrate (DEC) to at-risk populations. Anopheline mosquitoes are primary vectors of LF in Africa, and it is possible that the significant scale-up of malaria vector control over the past decade may have also impacted LF transmission, and contributed to a decrease in prevalence in Zambia. We therefore aimed to examine the putative association between decreasing LF prevalence and increasing coverage of insecticide-treated mosquito nets (ITNs) for malaria vector control, by comparing LF mapping data collected between 2003-2005 and 2009-2011 to LF sentinel site prevalence data collected between 2012 and 2014, before any anti-LF MDA was started. The coverage of ITNs for malaria was quantified and compared for each site in relation to the dynamics of LF. We found a significant decrease in LF prevalence from the years 2003-2005 (11.5% CI95 6.6; 16.4) to 2012-2014 (0.6% CI95 0.03; 1.1); at the same time, there was a significant scale-up of ITNs across the country from 0.2% (CI95 0.0; 0.3) to 76.1% (CI95 71.4; 80.7) respectively. The creation and comparis...Continue Reading

Citations

Jan 17, 2020·PLoS Neglected Tropical Diseases·Anne L WilsonSteve W Lindsay
Jul 26, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L W Niessen, M Taylor
Apr 25, 2018·Malaria Journal·Freddie MasaningaElizabeth Kawesha-Chizema
Jun 6, 2018·Parasites & Vectors·Joseph B KoromaYaobi Zhang
Aug 23, 2020·The Lancet Global Health·UNKNOWN Local Burden of Disease 2019 Neglected Tropical Diseases Collaborators

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Methods Mentioned

BETA
MDA

Software Mentioned

ArcGIS
ArcMap
R

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