PMID: 18432590Apr 25, 2008Paper

Significant decrease in dialysate albumin concentration during molecular adsorbent recirculating system (M.A.R.S.) therapy

The International Journal of Artificial Organs
D GongL Li

Abstract

The molecular adsorbent recirculating system (M.A.R.S.) is widely used as liver support therapy in patients with hepatic dysfunction. The goal of this study was to measure changes in dialysate albumin and bilirubin concentrations during clinical MARS treatments. Eight patients with acute liver dysfunction and hyperbilirubinemia were enrolled in this study. Five of them received a total of 10 treatments with MARS, in which 600 mL of 20% human albumin was used as dialysate, continuously regenerated by two adsorbent columns in the circuit. Three patients received 4 treatments of a modified MARS, in which the two adsorbent columns were bypassed in the first course for 4 h, and then connected to the circuit in the second course for another 4 h. The total, conjugated and unconjugated bilirubin (TB, CB, UCB) and albumin concentrations in serum and albumin dialysate were dynamically measured, and the adsorbent column inlet pressures were recorded during each session. In one session, dialysate albumin levels were measured during the priming process, at the time points prior to the priming process, immediately after priming, and at the end of the treatment. During MARS therapies, the reduction ratio of serum TB, CB and UCB was 26.6+/-9.0...Continue Reading

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Citations

Mar 23, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Betti SchaeferClaus Peter Schmitt
Sep 10, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Davide ViggianoCorrado Pluvio

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