Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus

Current Pharmaceutical Design
Marco Rinaldo OggioniBIOHYPO Consortium

Abstract

There is a growing concern by regulatory authorities for the selection of antibiotic resistance caused by the use of biocidal products. We aimed to complete the detailed information on large surveys by investigating the relationship between biocide and antibiotic susceptibility profiles of a large number of Staphylococcus aureus isolates using four biocides and antibiotics commonly used in clinical practice. The minimal inhibitory concentration (MIC) for most clinically-relevant antibiotics was determined according to the standardized methodology for over 1600 clinical S. aureus isolates and compared to susceptibility profiles of benzalkonium chloride, chlorhexidine, triclosan, and sodium hypochlorite. The relationship between antibiotic and biocide susceptibility profiles was evaluated using non-linear correlations. The main outcome evidenced was an absence of any strong or moderate statistically significant correlation when susceptibilities of either triclosan or sodium hypochlorite were compared for any of the tested antibiotics. On the other hand, correlation coefficients for MICs of benzalkonium chloride and chlorhexidine were calculated above 0.4 for susceptibility to quinolones, beta-lactams, and also macrolides. Our dat...Continue Reading

Citations

Jul 10, 2019·Expert Review of Anti-infective Therapy·Karolin HijaziIan M Gould
Jan 6, 2016·The Journal of Microbiology·Soojin Jang
Feb 26, 2019·Nature Microbiology·Roxana ZamudioKarolin Hijazi
Nov 11, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Neda BaseriBita Bakhshi
Sep 2, 2020·Poultry Science·Muhammad Ali SyedCharlene R Jackson
Jul 1, 2021·Clinical Microbiology Reviews·F BaqueroT M Coque
Nov 1, 2021·Journal of Industrial Microbiology & Biotechnology·Laura J FoxAndrew J McBain

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