Significant differences in central imaging of histamine-induced itch between atopic dermatitis and healthy subjects

European Journal of Pain : EJP
Gudrun SchneiderMatthias Weckesser

Abstract

This is the first investigation of the central processing of itch in the brain in 8 subjects with atopic dermatitis (AD) in comparison to 6 healthy controls (HC), comparing histamine-induced itch related activations in the frontal, prefrontal, parietal, cingulate cortex, thalamus, basal ganglia and cerebellum. We employed 1% histamine-dihydrochlorid-iontophoresis of the left hand, recorded H2(15)O-PET-scans and perception of itch intensity on a numeric rating scale. There was no significant difference in perceived itch intensity between AD and HC. Significant increase in rCBF was found in HC in the contralateral somatosensory and motor cortex, midcingulate gyrus, and ipsilateral prefrontal cortex; in AD: in the contralateral thalamus, somatosensory, motor and prefrontal cortex and cerebellum, in the ipsilateral precentral, prefrontal, orbitofrontal cortex, insula, pallidum and cerebellum. More brain sites were activated in AD than in HC. Activation in AD was significantly higher in the contralateral thalamus, ipsilateral caudate and pallidum. We interpret our findings as possible central correlates of changes in the motor system in subjects with chronic itch, with activation of the basal ganglia possibly correlating to the vici...Continue Reading

References

Dec 1, 1994·Journal of Neurophysiology·J C HsiehM Ingvar
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Ingvar
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
Apr 16, 2002·Experimental Dermatology·Sonja Ständer, Martin Steinhoff
Feb 7, 2003·Journal of the International Neuropsychological Society : JINS·Jean A Saint-Cyr
Feb 28, 2003·Lancet·Gil YosipovitchMartin Schmelz
Apr 2, 2003·Brain Research. Brain Research Reviews·Carl Y Saab, William D Willis
Apr 12, 2003·Brain : a Journal of Neurology·J LorenzK L Casey
Oct 29, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Carlo A Porro
Dec 31, 2003·Journal of the American Academy of Dermatology·Kenneth BenjaminJonathan L Rees
Apr 28, 2004·European Journal of Pain : EJP·G WasnerR Baron
May 26, 2004·Progress in Neurobiology·Morten L Kringelbach, Edmund T Rolls
Aug 25, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·M A Gupta, A K Gupta
Dec 8, 2004·Journal of the American Academy of Dermatology·Carol BringhurstJonathan L Rees
Dec 29, 2004·Pain·Akihiko IkomaMartin Schmelz
Jul 5, 2005·Nature Reviews. Neuroscience·Brent A Vogt
Aug 16, 2005·The Journal of Investigative Dermatology·B WalterU Gieler
Nov 22, 2005·Dermatologic Therapy·Martin Schmelz
Mar 17, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·S StänderM Schmelz
May 5, 2006·Brain : a Journal of Neurology·S F Cooke, T V P Bliss
May 9, 2006·European Journal of Pain : EJP·Sonja Ständer, Martin Schmelz
Jun 23, 2006·Nature Reviews. Neuroscience·Akihiko IkomaMartin Schmelz
Jun 27, 2006·Pain·M Schmelz
Oct 17, 2006·Clinical and Experimental Dermatology·G SchneiderS Ständer

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Citations

Jan 6, 2011·Clinical Reviews in Allergy & Immunology·Ulf DarsowSonja Ständer
Nov 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Henning HolleJamie Ward
Nov 22, 2011·Acta Dermato-venereologica·Andrea L SuárezMartin Steinhoff
Feb 5, 2011·Journal of the American Academy of Dermatology·Ashley R CurtisGil Yosipovitch
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Roland W FreudenmannCarlos Schönfeldt-Lecuona
Dec 9, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chie UsuiYuko Kikuchi
Jun 8, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C Potenzieri, B J Undem
Mar 27, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·C P Carlsson, J Wallengren
Jan 23, 2015·NeuroImage. Clinical·Gaëlle DesbordesVitaly Napadow
Jun 6, 2015·The Journal of Dermatology·Hideki Mochizuki, Ryusuke Kakigi
Dec 24, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hideki Mochizuki, Ryusuke Kakigi
Oct 15, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Robert Ch WolfRoland W Freudenmann
Jun 25, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Robert Christian WolfRoland W Freudenmann
Dec 30, 2014·Médecine sciences : M/S·Laurent Misery
Oct 1, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Hideki MochizukiGil Yosipovitch
Aug 28, 2009·Journal of Neurophysiology·Hideki MochizukiRyusuke Kakigi
Apr 9, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Peyman NajafiOlivier Dufor
Jul 24, 2020·The Journal of Dermatological Treatment·Michal RamonMichal Granot
Jul 1, 2019·Dermatology and Therapy·Mary Patricia SmithWilson Liao
Aug 10, 2017·Frontiers in Psychology·Christina SchutGil Yosipovitch
Jun 4, 2019·Frontiers in Physiology·Hideki MochizukiRyusuke Kakigi
Jun 18, 2020·Nature Communications·Xiao-Jun Chen, Yan-Gang Sun
Nov 5, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·P NajafiJ-L Carré
Jan 29, 2018·Neuroscience and Biobehavioral Reviews·Kristen M Sanders, Tasuku Akiyama
Mar 16, 2021·Frontiers in Medicine·Peyman NajafiOlivier Dufor
Dec 7, 2019·Journal of Neuroradiology. Journal De Neuroradiologie·Peyman NajafiOlivier Dufor
Aug 20, 2009·Current Opinion in Allergy and Clinical Immunology

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