PMID: 11910658Mar 26, 2002Paper

Significant differences in estradiol bioavailability from two similarly labelled estradiol matrix transdermal systems

Climacteric : the Journal of the International Menopause Society
A B BuchJ H Powell

Abstract

To compare the bioavailabilities of estradiol delivered by two transdermal estradiol matrix systems; Alora and Evorel. A single-center, open-label, randomized, two-period cross-over study in 33 postmenopausal women. The subjects received two successive 84-h applications of either Alora or Evorel (each labelled to deliver 50 micrograms/day 17 beta-estradiol) in a randomized sequence. Serial serum samples, collected over the 84-h period following the application of the second patch, were analyzed for estradiol using a validated radioimmunoassay method. The fluctuation index produced by Evorel was significantly higher than that produced by Alora (Evorel, 135%; Alora, 76%; p < 0.0005). In addition, the estradiol baseline-corrected area under the curve for Evorel was significantly lower than that for Alora (Alora, 2871.8 pg h/ml; Evorel, 1870.6 pg h/ml; p < 0.0005). Both patches were found to be generally well tolerated. Alora delivered a higher, more consistent concentration of estradiol into the systemic circulation over the entire dosing interval than did Everol. Although the full clinical significance of these findings is currently unknown, this study demonstrates that there are significant differences in estradiol delivery from...Continue Reading

References

May 1, 1990·The Nurse Practitioner·E Q Youngkin
Dec 1, 1989·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C RibotR Peyron
Jun 19, 1986·The New England Journal of Medicine·R J ChetkowskiH L Judd
Nov 1, 1995·Progress in Cardiovascular Diseases·I H Thorneycroft
Feb 1, 1994·American Journal of Obstetrics and Gynecology·M A Limouzin-LamotheM Le Gal
Sep 1, 1995·American Journal of Obstetrics and Gynecology·S F Gordon
Nov 15, 1995·Journal of the American College of Cardiology·S A Samaan, M H Crawford
Aug 2, 1997·BMJ : British Medical Journal·D RossM Whitehead
Aug 5, 1998·Menopause : the Journal of the North American Menopause Society·A BuchJ Powell
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A BowenW R Good

❮ Previous
Next ❯

Citations

Sep 10, 2002·Menopause : the Journal of the North American Menopause Society·Morris NotelovitzWilliam R Good
Apr 1, 2005·Climacteric : the Journal of the International Menopause Society·G Samsioe
Aug 29, 2012·Journal of Pharmaceutical Sciences·Jacquelyn Levin, Howard Maibach
Dec 23, 2008·International Journal of Pharmaceutics·Sara Farahmand, Howard I Maibach
Jun 15, 2004·Fertility and Sterility·Zeev Shoham, Gideon Kopernik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.