PMID: 8614235Mar 3, 1995Paper

Significant differences in the activity of midbrain dopamine neurons between male Fischer 344 (F344) and Lewis rats: an in vivo electrophysiological study

Life Sciences
Y MinabeC R Ashby

Abstract

There is a significant difference between the Lewis and Fischer 344 rats regarding their propensity to self-administer drugs of abuse. This study compares the number and the firing pattern of spontaneously active dopamine (DA) neurons in the substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in these two strains of rats. This was accomplished using the technique of in vivo extracellular recording. The number of spontaneously active DA neurons in the SNC and VTA of the Lewis rat were significantly lower compared to that of the F344 rats. Furthermore, a greater percentage of SNC and VTA DA neurons in the Lewis rats exhibited a burst firing pattern compared to F344 rats. These findings indicate that F344 and Lewis rats possess differences in mesolimbic DA neuronal activity and this may be a factor in explaining the different propensities between the two strains to self-administer drugs.

References

Jun 28, 1992·Annals of the New York Academy of Sciences·D Beitner-JohnsonE J Nestler
Feb 1, 1991·Brain : a Journal of Neurology·M T JohnsonT J Ebner
Jan 1, 1988·Annals of the New York Academy of Sciences·A A Grace
Oct 1, 1988·Alcoholism, Clinical and Experimental Research·F R George
Sep 1, 1988·Acta Physiologica Scandinavica·J GrenhoffT H Svensson
Feb 1, 1986·Drug and Alcohol Dependence·H de WitC E Johanson

❮ Previous
Next ❯

Citations

Jun 1, 1996·Brain Research. Cognitive Brain Research·J S Andrews
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Nathan A DeCarolisAnthony L Riley
Dec 26, 2001·Psychoneuroendocrinology·Therese A Kosten, Emilio Ambrosio
Jul 11, 1998·Alcoholism, Clinical and Experimental Research·S L Morzorati
Jun 2, 2006·Alcoholism, Clinical and Experimental Research·Sandra L Morzorati, Rita L Marunde
Apr 2, 2002·Expert Opinion on Investigational Drugs·Thomas R KostenTherese A Kosten
Apr 22, 2009·Behavioural Brain Research·Yavuz AyhanMikhail V Pletnikov
Jan 27, 2007·Neuroscience Letters·Yohtaro NumachiMitsumoto Sato

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.