Significant dose can be lost by extended delivery times in IMRT with x rays but not high-LET radiations

Medical Physics
Michael JoinerJay Burmeister

Abstract

To experimentally simulate IMRT delivery using two human cell models in vitro and test the hypothesis that a loss in effective dose resulting from the prolongation of megavoltage x-ray treatment delivery time would be greatly reduced in corresponding IMRT simulations using higher-LET radiation. The effect of prolonging the delivery time of a treatment fraction was investigated in vitro using human PC-3 prostate and HGL21 glioblastoma tumor cell lines. Cells were irradiated with x rays from a conventional linear accelerator or with neutrons from a clinical d(48.5)+Be radiotherapy beam and maintained at 37 degrees C throughout. The delivery time for six closely spaced doses, simulating six multiple-port segments, was varied from acute to 60 min for x-ray irradiation, and acute to 120 min for neutron irradiation. Cell survival was measured following summed doses for the six segments of 0.5-6 Gy for x rays and 0.16-2 Gy for neutrons, covering the most likely range of dose per fraction used in clinical radiotherapy. Prolonging x-ray delivery time (from initiation of segment 1 to initiation of segment 6) from 5 to 45 min resulted in a loss in effective total dose (in equivalent 2 Gy multifraction treatments) of 5.6% in the PC-3 cell ...Continue Reading

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Citations

Nov 4, 2011·Medical Physics·Richard A Popple, Ivan A Brezovich
Aug 8, 2013·International Journal of Radiation Oncology, Biology, Physics·Shervin M ShirvaniJoe Y Chang
Oct 10, 2015·The British Journal of Radiology·Alexandru Dasu, Iuliana Toma-Dasu
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Mar 11, 2017·Technology in Cancer Research & Treatment·Jan SeppäläJani Keyriläinen
Nov 22, 2017·Clinical & Experimental Metastasis·Benjamin J BlythOlga A Martin
Feb 23, 2018·The British Journal of Radiology·Roger G Dale
Mar 31, 2016·Physics in Medicine and Biology·P-H MackeprangP Manser
Jun 29, 2011·Physics in Medicine and Biology·Ndimofor ChoforBjörn Poppe

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