Significant elevation of serum caspase-3 levels in patients with intracerebral hemorrhage

Clinica Chimica Acta; International Journal of Clinical Chemistry
De-Biao SunHai-Tao Hu

Abstract

Caspase-3 is a potential marker of apoptosis. We investigated whether serum caspase-3 concentrations were increased and its association with severity and prognosis after intracerebral hemorrhage (ICH). This prospective clinical study recruited 112 ICH patients and 112 healthy individuals. Serum was assayed for caspase-3 using enzyme-linked immunosorbent assay. Stroke severity was quantified by National Institute of Health Stroke Scale (NIHSS) and hematoma volume. Six-month outcome was measured by modified Rankin Scale. Analyses were performed using univariate and multivariate analyses. Patients had significantly higher serum caspase-3 concentrations than controls. Capase-3 concentrations correlated with NIHSS score and hematoma volume. Serum caspase-3 emerged as an independent predictor for 6-month mortality and bad prognosis (modified Rankin scale score>2). Based on receiver operating characteristic curve, caspase-3 concentrations showed similar prognostic value when compared with NIHSS score and hematoma volume. Serum caspase-3 concentrations are increased in ICH patients as well as correlate with clinical severity and prognosis.

Citations

Feb 1, 2020·Fetal and Pediatric Pathology·Meliha Aksoy OkanGüner Karatekin
Aug 15, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jean Alex Matos RibeiroThiago Luiz Russo

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