PMID: 9821041Nov 20, 1998

Significant elevation of urinary 28-kD calbindin-D and N-acetyl-beta-D-glucosaminidase levels in patients undergoing extracorporeal shock wave lithotripsy

International Urology and Nephrology
M TakashiK Kato

Abstract

Calbindin-D, a vitamin D-dependent calcium binding protein with a molecular mass of 28 kD, is found predominantly in distal renal tubules and central nervous system tissues in man. We have developed a highly sensitive enzyme immunoassay for human 28-kD calbindin-D and demonstrated its advantages as a new marker for damage to distal renal tubules. Urinary N-acetyl-beta-D-glucosaminidase (NAG), a lysosomal enzyme of the proximal renal tubules, is another segment-specific indicator of renal damage. To clarify whether both proximal and distal renal tubules are similarly affected by extracorporeal shock wave lithotripsy (SWL) treatment, urinary 28-kD calbindin-D and NAG were measured before, then immediately, 2 and 24 hours after SWL in 17 renal lithiasis patients. Levels of urinary calbindin-D were markedly elevated immediately and 2 hours after SWL and then decreased. In sera, levels of calbindin-D also increased, closely correlated with the changes in urinary values. Levels of urinary NAG were also significantly elevated immediately after SWL and then decreased. The results indicate that damage to both proximal and distal renal tubules occurs simultaneously with SWL and that the two markers can be applied as sensitive indicators ...Continue Reading

References

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Sep 30, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y Y ZhuK Kato
Sep 1, 1989·The Journal of Urology·D G AssimosD L McCullough
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Related Concepts

Beta-N-Acetylglucosaminidase
Beta-2 Microglobulin
Macro-Creatine Kinase
Enzyme-Linked Immunosorbent Assay
Kidney Calculi
Lactate Dehydrogenase
Percutaneous Ultrasonic Lithotripsy
Calbindins
Calcium-Binding Protein, Vitamin D-Dependent

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