Significant exposures to isoeugenol derivatives in perfumes

Contact Dermatitis
Suresh C Rastogi, Jeanne D Johansen

Abstract

Isoeugenol, an important fragrance allergen in consumers, has been restricted to 200 p.p.m. since 1998 according to guidelines issued by the fragrance industry. However, no decline in contact allergy to isoeugnol has been detected. It has been speculated that isoeugenol derivatives, especially isoeugenyl acetate, are used instead. Isoeugenyl acetate is probably metabolized in the skin to isoeugenol and gives positive patch test reactions in 1/3 of isoeugenol-sensitized individuals. To investigate the content of isoeugenol, isoeugenyl acetate, and two isoeugenol ethers in perfumes/aftershaves. 29 international brand perfumes/aftershaves were analysed for the target fragrance ingredient by gas chromatography-mass spectrometry. All samples were analysed in duplicate at detection levels of 1-5 p.p.m. 16 products (55%) contained isoeugenol. The maximum concentration was 202 p.p.m. 10 products (34%) contained isoeugenyl acetate, which in 9 cases occurred together with isoeugenol. The concentrations of isoeugenyl acetate ranged from 20 to 4689 p.p.m. 13 products (44%) contained 64.9-1755.0 p.p.m. isoeugenyl methyl ether. Isoeugenyl benzyl ether was not detected in any of the investigated products. Isoeugenyl acetate is present in perf...Continue Reading

References

May 1, 1977·Archives of Dermatology·W G Larsen
Mar 24, 2000·The British Journal of Dermatology·D A BuckleyJ P McFadden
Oct 31, 2001·Contact Dermatitis·S C RastogiD A Basketter

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Citations

Jan 11, 2014·Dermatitis : Contact, Atopic, Occupational, Drug·David A BasketterMarie Templier
Jan 21, 2012·International Journal of Hygiene and Environmental Health·Ursula Klaschka
Feb 12, 2009·Contact Dermatitis·Andrea NardelliAn Goossens
Jan 18, 2013·Integrated Environmental Assessment and Management·Ursula Klaschka
Nov 13, 2018·Journal of Toxicology and Environmental Health. Part a·Duck Soo LimByung-Mu Lee

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