Significant fibrosis predicts new-onset diabetes mellitus and arterial hypertension in patients with NASH.

Journal of Hepatology
Javier AmpueroHEPAmet Registry

Abstract

Non-alcoholic fatty liver disease (NAFLD) could play a catalytic role in the development of metabolic comorbidities, although the magnitude of this effect in metabolically healthy patients with NAFLD remains unclear. We assessed the role of biopsy-proven NAFLD on the risk of developing type 2 diabetes mellitus (T2DM) and other metabolic comorbidities (arterial hypertension [AHT], and dyslipidemia) in metabolically healthy patients. We included 178 metabolically healthy-defined by the absence of baseline T2DM, AHT, dyslipidemia-patients with biopsy-proven NAFLD from the HEPAmet Registry (N = 1,030). Hepamet fibrosis score (HFS), NAFLD fibrosis score, and Fibrosis-4 were calculated. Follow-up was computed from biopsy to the diagnosis of T2DM, AHT, or dyslipidemia. During a follow-up of 5.6 ± 4.4 years, T2DM occurred in 9% (16/178), AHT in 8.4% (15/178), low HDL in 9.6% (17/178), and hypertriglyceridemia in 23.6% (42/178) of patients. In multivariate analysis, significant fibrosis predicted T2DM and AHT. Independent variables related to T2DM appearance were significant fibrosis (HR 2.95; 95% CI 1.19-7.31; p = 0.019), glucose levels (p = 0.008), age (p = 0.007) and BMI (p = 0.039). AHT was independently linked to significant fibros...Continue Reading

Citations

Jan 12, 2021·Digestive Diseases and Sciences·Fátima Higuera-de-la-TijeraCarlos Moctezuma-Velazquez
Feb 3, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Paula IruzubietaJavier Crespo
Apr 9, 2021·Advances in Therapy·Amedeo LonardoMarco Arrese
May 12, 2021·Nature Reviews. Gastroenterology & Hepatology·Giovanni TargherMichael Roden
Jun 3, 2021·Journal of Clinical Medicine·Carolina M PerdomoJavier Escalada
Jun 23, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Douglas Maya-MilesManuel Romero-Gómez
Jul 10, 2021·Seminars in Liver Disease·Anas HashemAndres Acosta
Nov 4, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·José Ignacio Martínez-MontoroBruno Ramos-Molina

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