Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68.

Journal of Oncology
Ivaylo GentschevAladar A Szalay

Abstract

Canine mammary carcinoma is a highly metastatic tumor that is poorly responsive to available treatment. Therefore, there is an urgent need to identify novel agents for therapy of this disease. Recently, we reported that the oncolytic vaccinia virus GLV-1h68 could be a useful tool for therapy of canine mammary adenoma in vivo. In this study we analyzed the therapeutic effect of GLV-1h68 against canine mammary carcinoma. Cell culture data demonstrated that GLV-1h68 efficiently infected and destroyed cells of the mammary carcinoma cell line MTH52c. Furthermore, after systemic administration, this attenuated vaccinia virus strain primarily replicated in canine tumor xenografts in nude mice. Finally, infection with GLV-1h68 led to strong inflammatory and oncolytic effects resulting in significant growth inhibition of the tumors. In summary, the data showed that the GLV-1h68 virus strain has promising potential for effective treatment of canine mammary carcinoma.

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Citations

Jun 15, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Duong H NguyenAladar A Szalay
Aug 2, 2012·American Journal of Veterinary Research·Ashlee S UrbasicAmy L MacNeill
May 21, 2014·Viruses·Ivaylo GentschevAladar A Szalay
Apr 28, 2016·Molecular Therapy Oncolytics·Koichiro ShojiChieko Kai
Aug 1, 2018·Viruses·Amy L MacNeillBarbara E Powers
Jul 25, 2014·Journal of Virology·Jochen StritzkerAladar A Szalay
Oct 31, 2018·Cancers·Diana SánchezMarcela Lizano
Mar 9, 2021·Frontiers in Veterinary Science·Guillermo ValdiviaLaura Peña
Jan 6, 2012·Journal of Translational Medicine·Sandeep S PatilAladar A Szalay

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Methods Mentioned

BETA
xenograft
xenografts
Assay
electrophoresis
fluorescence microscopy
flow cytometry

Software Mentioned

GraphPad Prism
Photoshop
Image WinLight

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