Abstract
Canine mammary carcinoma is a highly metastatic tumor that is poorly responsive to available treatment. Therefore, there is an urgent need to identify novel agents for therapy of this disease. Recently, we reported that the oncolytic vaccinia virus GLV-1h68 could be a useful tool for therapy of canine mammary adenoma in vivo. In this study we analyzed the therapeutic effect of GLV-1h68 against canine mammary carcinoma. Cell culture data demonstrated that GLV-1h68 efficiently infected and destroyed cells of the mammary carcinoma cell line MTH52c. Furthermore, after systemic administration, this attenuated vaccinia virus strain primarily replicated in canine tumor xenografts in nude mice. Finally, infection with GLV-1h68 led to strong inflammatory and oncolytic effects resulting in significant growth inhibition of the tumors. In summary, the data showed that the GLV-1h68 virus strain has promising potential for effective treatment of canine mammary carcinoma.
References
Feb 1, 1994·British Heart Journal·Y AgataT Shimoda
Jul 11, 2003·The Veterinary Clinics of North America. Small Animal Practice·Karin Sorenmo
Sep 27, 2005·The Journal of Dairy Research·Eva Hellmén
Jan 30, 2007·Nature Clinical Practice. Oncology·Ta-Chiang LiuDavid Kirn
Mar 10, 2007·Current Cancer Drug Targets·Anne Moon Crompton, David H Kirn
Mar 27, 2007·Cancer Letters·Markus J V Vähä-KoskelaAri E Hinkkanen
Oct 19, 2007·Cancer Research·Qian ZhangAladar A Szalay
Dec 8, 2007·Surgery·Shu-Fu LinRichard J Wong
Jan 23, 2008·Cellular Microbiology·Stephanie WeibelAladar A Szalay
Jun 17, 2008·Nature Reviews. Microbiology·Roberto CattaneoMichael A Barry
Aug 14, 2008·The Journal of Clinical Endocrinology and Metabolism·Shu-Fu LinRichard J Wong
Aug 30, 2008·Human Gene Therapy·Kaitlyn J KellyYuman Fong
Oct 25, 2008·Cancer Gene Therapy·I GentschevA A Szalay
Dec 9, 2008·Gene·Katharina A SterenczakHugo Murua Escobar
Dec 24, 2008·Nature Reviews. Cancer·David H Kirn, Steve H Thorne
Jan 14, 2009·Molecular Cancer Therapeutics·Yong A YuAladar A Szalay
Mar 7, 2009·Cancer Immunology, Immunotherapy : CII·Andrea WorschechAladar A Szalay
Jul 9, 2009·BMC Genomics·Andrea WorschechFrancesco M Marincola
Apr 10, 2010·Journal of Biomedicine & Biotechnology·Ivaylo GentschevAladar A Szalay
Citations
Jun 15, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Duong H NguyenAladar A Szalay
Sep 29, 2011·Journal of Translational Medicine·Nanhai G ChenAladar A Szalay
Jul 23, 2011·PloS One·Ivaylo GentschevAladar A Szalay
May 23, 2012·PloS One·Ivaylo GentschevAladar A Szalay
Aug 23, 2012·PloS One·Dana HaddadYuman Fong
Oct 24, 2012·PloS One·Sandeep S PatilAladar A Szalay
Aug 2, 2012·American Journal of Veterinary Research·Ashlee S UrbasicAmy L MacNeill
May 21, 2014·Viruses·Ivaylo GentschevAladar A Szalay
Apr 28, 2016·Molecular Therapy Oncolytics·Koichiro ShojiChieko Kai
Nov 21, 2015·Cancer Gene Therapy·Amudhan PugalenthiYuman Fong
Oct 25, 2012·Bioengineered·Ivaylo GentschevAladar A Szalay
Dec 9, 2014·Bioengineered·Alexander CecilAladar A Szalay
Aug 6, 2014·PloS One·Marion AdelfingerAladar A Szalay
Jul 25, 2015·Viruses·Marion AdelfingerAladar A Szalay
Aug 1, 2018·Viruses·Amy L MacNeillBarbara E Powers
Jul 25, 2014·Journal of Virology·Jochen StritzkerAladar A Szalay
Sep 11, 2010·Cancer Gene Therapy·C M SeubertA A Szalay
Jul 1, 2011·The Journal of General Virology·Brian C DeHavenStuart N Isaacs
Apr 5, 2020·Viruses·Jianjun ZhaoDongbo Sun
Jun 5, 2017·Archives of Virology·Kishan K SharmaBhavesh Vyas
Oct 11, 2014·Veterinary and Comparative Oncology·K AutioA Hemminki
Oct 31, 2018·Cancers·Diana SánchezMarcela Lizano
Apr 14, 2018·BMC Cancer·Melissa M LedetGerlinde R Van de Walle
Mar 9, 2021·Frontiers in Veterinary Science·Guillermo ValdiviaLaura Peña
Jan 6, 2012·Journal of Translational Medicine·Sandeep S PatilAladar A Szalay
Jul 18, 2014·Journal of Translational Medicine·Elisabeth HofmannAladar A Szalay