Significant hepatic expression of IL-2 and IL-8 in biliary atresia compared with other neonatal cholestatic disorders

Cytokine
Reda Sanad ArafaMostafa M Sira

Abstract

Although the exact etiology of biliary atresia (BA) is still elusive, inflammation plays a key role. Release of proinflammatory cytokines from activated immune cells perpetuates the injury and causes biliary destruction. We aimed to study interleukin (IL)-2 and IL-8 expression in liver tissue of BA patients compared with other neonatal cholestatic disorders. The study included 59 infants with neonatal cholestasis in two groups; BA group (n=31) and non-BA group (n=28) with cholestatic disorders other than BA as controls. Demographic, clinical, laboratory, and histopathological parameters were collected. IL-2 and IL-8 immunostaining was performed. Immunostaining in portal cellular infiltrate was scored as positive or negative and expressed as the mean cell count in three portal tracts. The mean value of IL-2 and IL-8 positive inflammatory cells was significantly higher in BA than in non-BA group (P-values of 0.004 and 0.002 respectively). IL-2 correlated significantly with IL-8 immunostaining in both BA and non-BA group (P<0.0001 for both). Furthermore, both cytokines in both groups correlated significantly with inflammatory activity in liver biopsy while there was no significant correlation with the other studied parameters. Yet...Continue Reading

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Citations

May 7, 2016·Gastroenterology·Christian KlemannJoachim F Kuebler
Nov 26, 2019·Journal of Pediatric Gastroenterology and Nutrition·Ola G BehairyKamal R Sayied
May 8, 2019·Hepatology Communications·Sehee KimUNKNOWN Childhood Liver Disease Research Network
Jun 8, 2017·Gastroenterology Research and Practice·Shaimaa Samy GodaMostafa Mohamed Sira
Jul 3, 2021·Journal of Clinical Medicine·Nimish GodboleMikko P Pakarinen

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