Significant in vivo anti-inflammatory activity of Pytren4Q-Mn a superoxide dismutase 2 (SOD2) mimetic scorpiand-like Mn (II) complex

PloS One
Carolina SerenaAntonio García-España

Abstract

The clinical use of purified SOD enzymes has strong limitations due to their large molecular size, high production cost and immunogenicity. These limitations could be compensated by using instead synthetic SOD mimetic compounds of low molecular weight. We have recently reported that two SOD mimetic compounds, the Mn(II) complexes of the polyamines Pytren2Q and Pytren4Q, displayed high antioxidant activity in bacteria and yeast. Since frequently molecules with antioxidant properties or free-radical scavengers also have anti-inflammatory properties we have assessed the anti-inflammatory potential of Pytren2Q and Pytren4Q Mn(II) complexes, in cultured macrophages and in a murine model of inflammation, by measuring the degree of protection they could provide against the cellular injury produced by lipopolisacharide, a bacterial endotoxin. In this report we show that the Mn(II) complex of Pytren4Q but not that of Pytren2Q effectively protected human cultured THP-1 macrophages and whole mice from the inflammatory effects produced by LPS. These results obtained with two molecules that are isomers highlight the importance of gathering experimental data from animal models of disease in assessing the potential of candidate molecules. The...Continue Reading

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Citations

Feb 5, 2016·Molecular Metabolism·Victòria Ceperuelo-MallafréSonia Fernández-Veledo
Nov 5, 2016·Journal of Inorganic Biochemistry·Jorge González-GarcíaAntonio Garcia-España
Jan 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carole Nicco, Frédéric Batteux
Mar 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Matteo SavastanoCarla Bazzicalupi
Jul 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Álvaro Martínez-CamarenaEnrique García-España
May 6, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·A LiberatoB Verdejo
Dec 23, 2021·Inorganic Chemistry·Álvaro Martínez-CamarenaCarla Bazzicalupi

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Methods Mentioned

BETA
PMA
Assay
ELISA
protein assay
PCR

Software Mentioned

RQ Manager
GraphPad Prism
AnaliSYS
SPSS
GraphPad

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