Significant interaction between LRP2 rs2544390 in intron 1 and alcohol drinking for serum uric acid levels among a Japanese population

Gene
Nobuyuki HamajimaKenji Wakai

Abstract

A genome-wide association study identified that LRP2 rs2544390 in intron 1 was associated with serum uric acid (SUA) levels among Japanese, as well as polymorphisms of SLC22A12, ABCG2, and SLC2A9. This study aimed to confirm the association of rs2544390 C/T with SUA, as well as another LRP2 polymorphism (rs3755166 G/A) in the promoter. Subjects were 5016 health checkup examinees (3409 males and 1607 females) aged 35 to 69years with creatinine<2.0mg/dL. The subjects with SLC22A12 258WW, SLC2A9 rs11722228C allele, ABCG2 126QQ and 141Q allele (2546 males and 1199 females) were selected for analysis. Mean SUA was 6.03mg/dL for CC, 6.18mg/dL for CT, and 6.19mg/dL for TT among males (p=0.012), and 4.49mg/dL, 4.45mg/dL, and 4.42mg/dL among females (not significant), respectively. No association was observed for rs3755166. The association with rs2544390 was stronger among male drinkers. The odds ratio of drinking ≥5/week relative to no drinking for hyperuricemia (SUA≥7mg/dL and/or under medication for hyperuricemia) was 1.11 (95% confidence interval, 0.67-1.84) among CC males, 1.75 (1.22-2.51) among CT males, and 3.13 (1.80-5.43) among TT males. The interaction terms with drinking ≥5/week were 1.56 (p=0.156) for CT and 2.87 (p=0.005) f...Continue Reading

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Citations

Apr 8, 2014·Rheumatic Diseases Clinics of North America·Tony R MerrimanNicola Dalbeth
Dec 24, 2018·Current Opinion in Rheumatology·Vicky TaiNicola Dalbeth
Dec 15, 2012·Journal of Atherosclerosis and Thrombosis·Fumihiko TakeuchiNorihiro Kato
Oct 17, 2019·The Journal of Rheumatology·Jaelim ChoMaxim S Petrov
Aug 10, 2012·Physiology·Erik I ChristensenRikke Nielsen
Jun 2, 2017·BMC Medicine·Nicola DalbethTony R Merriman
Jul 7, 2017·Arthritis Research & Therapy·Humaira RasheedTony R Merriman
Mar 9, 2021·Seminars in Nephrology·Megan P LeaskTony R Merriman

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