PMID: 11606796Oct 19, 2001Paper

Significant shortcomings of the U.S. Environmental Protection Agency's latest draft risk characterization for dioxin-like compounds

Toxicological Sciences : an Official Journal of the Society of Toxicology
T B Starr

Abstract

The United States Environmental Protection Agency (U.S. EPA) has concluded that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a human carcinogen, and it has stated that the lifetime all-cancer mortality risk attributable solely to the current background body burden of dioxin-like compounds could be as high as 1.3 per 100. U.S. EPA's most current human cancer risk estimate was obtained from a linear dose-response model fit to the data from three epidemiology studies of TCDD-exposed chemical workers. Herein it is shown that the U.S. EPA model fails to provide an adequate fit to that data, whereas an intercept-only model, having no slope whatsoever, is entirely adequate. Although the epidemiology data used by U.S. EPA are consistent with a significant elevation in all-cancer mortality, by about 32%, among TCDD-exposed workers, this elevation should not be attributed to the workers' TCDD exposure.

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Citations

Feb 26, 2004·Free Radical Biology & Medicine·Howard G ShertzerTimothy P Dalton
Nov 19, 2003·Regulatory Toxicology and Pharmacology : RTP·Philip ColeJack S Mandel
Nov 7, 2001·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·C E Dallas, P L Williams
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Pamela R D Williams, Dennis J Paustenbach
Jan 30, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Jessica F GreeneDennis Paustenbach
Apr 15, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Dennis J PaustenbachBrent D Kerger
Nov 13, 2003·Journal of Toxicology and Environmental Health. Part a·P Robinan GentryMelvin E Anderson
May 3, 2003·Environmental Health Perspectives·Kenny S CrumpManolis Kogevinas
Sep 4, 2004·Environmental Health Perspectives·Kyle SteenlandManolis Kogevinas
Aug 29, 2006·Journal of the Air & Waste Management Association·C Andrew MillerJ David Mobley
Mar 28, 2008·International Journal of Environmental Health Research·Arild VaktskjoldEvert Nieboer
Jan 1, 2005·Nonlinearity in Biology, Toxicology, Medicine·Morton Lippmann
Apr 15, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Kevin T Connor, Lesa L Aylward
Aug 5, 2003·Environmental Health Perspectives·Albert Donnay
Aug 5, 2003·Environmental Health Perspectives·John H LangeYue-Fang Chang
Aug 5, 2003·Environmental Health Perspectives·Lesa AylwardSean Hays
Sep 2, 2003·Environmental Health Perspectives·Thomas B Starr
Nov 4, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·James A PoppErnest E McConnell
Aug 2, 2005·Regulatory Toxicology and Pharmacology : RTP·Michael Schwarz, Klaus E Appel

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