Significant thresholds for the 75-g oral glucose tolerance test in pregnancy

Journal of Diabetes and Its Complications
C Savona-Ventura, M Chircop

Abstract

The significant threshold values for the 75-g oral glucose tolerance test (oGTT) during pregnancy have yet to be conclusively determined. This study aimed to identify the risk significance of various set thresholds for the oGTT result. Women undergoing a 75-g oGTT during the third trimester of pregnancy were classified into three groups: mild gestational impaired glucose tolerance (GIGT; 2-h postload glucose, 8.0-8.5 mmol/l; n=75), moderate-severe GIGT (8.6-10.9 mmol/l; n=167), and GDM (> or =11.0 mmol/l; n=76). Outcome indicators of these three groups of women were compared to the parameters of the women with a presumed normal carbohydrate metabolism (n=12,185). The results show that with increasing oGTT thresholds, there was an increasing risk of maternal morbidity in the form of hypertensive disorders complicating pregnancy, as well as obstetric intervention such as induction of labor, cesarean delivery, and preterm delivery. The infant was also at increasing risk with increasing oGTT thresholds from respiratory distress, macrosomia, and associated shoulder dystocia. It would appear, therefore, that abnormal glucose tolerance in pregnancy, even as defined by the World Health Organization criteria, has proportionate risks to ...Continue Reading

References

Jul 13, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN HAPO Study Cooperative Research Group
Jul 31, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A G Schranz, C Savona-Ventura

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Citations

Apr 6, 2011·The Journal of Obstetrics and Gynaecology Research·Oktay KaymakNuri Danisman
May 19, 2009·British Journal of Nursing : BJN·Catherine Hayes
Nov 8, 2008·Current Opinion in Obstetrics & Gynecology

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