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Significant Upregulation of Alzheimer's β-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides

Angewandte Chemie

Oct 14, 2019

Chao MaCan Zhang

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder and the primary cause of age-related dementia. The etiology of AD is complex and has not been completely elucidated. Herein, we report that treatment with elastin-like polypeptides (ELPs), a component of the brain extracellular ma...read more

Mentioned in this Paper

Alzheimer's Disease
Brain
Elastin
Extracellular Fluid
Extracellular Matrix
Up-Regulation (Physiology)
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Impaired Cognition
Dementia
9
3
3
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Significant Upregulation of Alzheimer's β-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides

Angewandte Chemie

Oct 14, 2019

Chao MaCan Zhang

PMID: 31609093

DOI: 10.1002/anie.201912399

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder and the primary cause of age-related dementia. The etiology of AD is complex and has not been completely elucidated. Herein, we report that treatment with elastin-like polypeptides (ELPs), a component of the brain extracellular ma...read more

Mentioned in this Paper

Alzheimer's Disease
Brain
Elastin
Extracellular Fluid
Extracellular Matrix
9
3
3

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Paper Details
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  • Citations
123
  • References26
  • Citations
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