PMID: 9008223Feb 1, 1997Paper

Significantly increased occurrence of HLA-DQB1*0301 allele in patients with ocular cicatricial pemphigoid

The Journal of Investigative Dermatology
L S ChanK D Cooper

Abstract

To determine the immunogenetic characteristics of patients with immune-mediated subepithelial blistering diseases of mucous membranes, we performed HLA-typing for the class II MHC gene DQB1*0301 allele using a direct method. Genomic DNA extracted from Caucasian patients was amplified by polymerase chain reaction using primer pairs specific for the DQB loci followed by Southern blotting with a peroxidase-conjugated sequence-specific oligonucleotide probe. Seventy-six percent (16/21) of patients with ocular mucosal disease (with or without oral mucosal and skin diseases) carried the DQB1*0301 allele; by contrast, only 33% (14/42) of race-, age-, and geography-matched normal individuals carried the DQB1*0301 allele (p < 0.005). The relative risk for ocular disease if DQB1*0301 allele is present is 6.4, similar to the relative risk of 8 for patients with ocular but no oral disease (pure ocular cicatricial pemphigoid, p < 0.025). In patients with oral mucosal disease (with or without ocular mucosal and skin diseases), 68% (15/22) carried the DQB1*0301 allele (p < 0.025). When patients with ocular disease were excluded, however, the increased occurrence of the DQB1*0301 allele in patients with oral disease was not statistically signi...Continue Reading

Citations

Sep 25, 1998·The British Journal of Dermatology·C C BanfieldK I Welsh
May 3, 2000·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M DrouetM Cogné
Jun 30, 2005·Oral Diseases·J BaganC Scully
Apr 25, 2000·The Journal of Dermatology·A OkazakiT Shirai
Jul 25, 2006·Medicine·Marina AlexandreCatherine Prost-Squarcioni
Aug 6, 2017·Clinical Reviews in Allergy & Immunology·Kyle T AmberLuca Borradori
May 8, 1999·The British Journal of Dermatology·G KirtschigR Happle
Nov 15, 2017·Experimental Dermatology·Christian D SadikSaleh M Ibrahim
Jan 23, 1999·Clinical and Experimental Dermatology·G KirtschigR Happle
Oct 15, 2020·Biomolecules·Francesco MoroGiovanni Di Zenzo
Sep 17, 2013·Dental Clinics of North America·Hong-Hui XuThomas P Sollecito
Sep 27, 2000·Journal of the American Academy of Dermatology·T E Fleming, N J Korman

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