Significantly lengthened telomere in granulosa cells from women with polycystic ovarian syndrome (PCOS)

Journal of Assisted Reproduction and Genetics
Duo WeiYingpu Sun

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among women at reproductive age. However, its etiology remains poorly understood. Recent studies indicated that telomere length was related to PCOS. However, the association between telomere length and PCOS has only been shown in leucocytes and remained controversial across different studies. To clarify the association between telomere length and PCOS, the current study interrogated telomere length not only in leucocytes, but also in follicular granulosa cells, which is essential for folliculogenesis and steroidogenesis. Seventy-five patients with PCOS and 81 controls with mechanical infertility undergoing their first in vitro fertilization cycle were enrolled. Their peripheral blood and granulosa cells were collected on the oocyte retrieval day. Telomere length of both leucocytes in the blood and granulosa cells was assayed by quantitative polymerase chain reaction. No significant difference was found in the leucocyte telomere length between controls and PCOS patients (0.99 ± 0.44 vs. 1.00 ± 0.38, p = 0.93). Interestingly, when comparing telomere length in granulosa cells between controls and PCOS subjects, significantly lengthened telomere length was found in ...Continue Reading

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Citations

Oct 3, 2018·The Journal of Reproduction and Development·Esra Gozde KosebentSaffet Ozturk
Oct 3, 2018·Biology of Reproduction·Maria Santa RoccaAlberto Ferlin
Oct 10, 2018·Reproductive Sciences·Luis Alejandro Arias-Sosa
Jun 8, 2019·International Journal of Molecular Medicine·Eleni VasilopoulosAristidis Tsatsakis
Aug 29, 2020·Journal of Assisted Reproduction and Genetics·Fatma UysalSaffet Ozturk
Apr 8, 2021·Reproductive Sciences·Matheus Credendio EirasCristiana Libardi Miranda Furtado
Jun 1, 2021·Frontiers in Endocrinology·Mariela Edith VelazquezGloria Edith Cerrone
Aug 7, 2021·Biomedicines·Simon ToupanceIsabelle Koscinski

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