Signs of continental ancestry in urban populations of Peru through autosomal STR loci and mitochondrial DNA typing

PloS One
Francesco MessinaCarla Jodice

Abstract

The human genetic diversity around the world was studied through several high variable genetic markers. In South America the demic consequences of admixture events between Native people, European colonists and African slaves have been displayed by uniparental markers variability. The mitochondrial DNA (mtDNA) has been the most widely used genetic marker for studying American mixed populations, although nuclear markers, such as microsatellite loci (STRs) commonly used in forensic science, showed to be genetically and geographically structured. In this work, we analyzed DNA from buccal swab samples of 296 individuals across Peru: 156 Native Amazons (Ashaninka, Cashibo and Shipibo from Ucayali, Huambiza from Loreto and Moche from Lambayeque) and 140 urban Peruvians from Lima and other 33 urban areas. The aim was to evaluate, through STRs and mtDNA variability, recent migrations in urban Peruvian populations and to gain more information about their continental ancestry. STR data highlighted that most individuals (67%) of the urban Peruvian sample have a strong similarity to the Amazon Native population, whereas 22% have similarity to African populations and only ~1% to European populations. Also the maternally-transmitted mtDNA con...Continue Reading

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Methods Mentioned

BETA
genotyping
PCR
PCA

Software Mentioned

NativesSArgentinaChile
PuntaArenas
TemucoChile
Passage
ConceptionChile
R package factoextra
R package plot3D
SubAndeBolivia
R script
GeneMapper ® ID - X

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